“Anti-estrogens & Women”
By Sassy69
There are two classes of estrogen manipulators that often fall under the term “anti-estrogens”. The first are Selective Estrogen Receptor Manipulators (SERMs).
The only current example out there is Tamoxifen Citrate (brand name: Nolvadex). This operates specifically on the ovarian-driven estrogen process. The second category that falls under “anti-estrogens” are Aromatase Inhibitors (AI’s) that operate not on ovary-originating estrogen, but rather that resulting from aromatization (or conversion to estrogen) of testosterone. Examples of testosterones that convert are exogenous testosterones (anabolic androgenic steroids) such as Testosterone Propionate, Nandrolone Decoanate (“Deca”), or Dianabol (“d-bol”). There is also a natural source of androgen that converts to estrogen – that produced by the adrenal glands, in both men and women. When women enter menopause and their ovary-originating estrogen is no longer produced, the only remaining source of naturally produced estrogen is that resulting from the adrenals. Examples of AI’s are Arimidex, Aromasin and Letrozole. In practice, both these and Nolvadex, are all primarily prescribed as breast cancer treatment for post-menopausal women.
Women are more likely to use a SERM like Nolvadex to address the bodyfat associated with estrogen – specifically the stuff that tends to collect around the hips, thighs, lower abdomen and butt. It is important to note that each person has her own distribution of fat cells – estrogen tends to promote a higher concentration of fat cells in those lower areas as part of a natural preservation strategy to protect a fetus and also to provide an extra storage of energy source (bodyfat) to help support a growing fetus and the mother if there is any issue with available food sources (i.e. a drought scenario). This is by design and using an estrogen inibitor as a weight-loss strategy is not a good idea. Estrogen is one of the three basic hormones that make up who we are, and drive everything from moods to how we look and feel. Estrogen is there for a purpose and should not be completely suppressed only for the purpose of fat loss.
Nolvadex acts to fake out the estrogen receptors (envision a safety protector that you put into outlets as part of baby-proofing your house) and essentially cutting off the estrogen process, instead of literally turning it off. For cycle duration, it is recommended to keep it to 4-8 weeks maximum. Long-term use of Nolvadex has the potential to introduce health issues as described in this article: Side effects of long-term use of tamoxifen (http://www.livestrong.com/article/37...use-tamoxifen/). .In the extreme, full estrogen shut down in women can lead to what is often referred to as the “Female Athlete Triad” – basically estrogen shutdown as a result of an eating disorder such as anorexia, which leads to reduction in calcium, and eventually to brittle bones and a host of other issues related to a stopped period. Here is an overview of this particular issue: http://www.womenssportsfoundation.or...ick-Facts.aspx. Though this discussion is not focused on eating disorders, the end result, if someone decided to use medical estrogen suppression as a long-term weightloss protocol, is the same. This is just to reinforce that this is not a good idea.
The estrogen process tends to be fairly resilient so coming off a reasonable duration cycle can produce an estrogen rebound when the process is no longer inhibited. There isn’t much documentation about this rebound, but general guidance is to taper off a cycle by reducing the dose (e.g. in half, every 3 days).
In the context of this article, Aromatase Inhibitors are more specific to the estrogen produced as a result of using an aromatizing steroid. This means that the steroid cycle is more aggressive and will produce side effects such as water retention and potentially more mood swings, as the converted estrogen may be adding to natural estrogen levels, enhancing typical estrogen effects that might be experienced during a menstrual cycle. AI’s are more commonly used by men who cycle as the increase in estrogen can produce such side effects in men as gynocomastia (enlarged breast tissue), water retention, mood swings, etc. For men, as well as women, full estrogen suppression is not helpful if the goal is to build muscle as water (e.g. from estrogen) is needed to create a “growth environment” in the muscle. . (This article is more geared towards men and the use of AIs to prevent gynecomastia, it still gives some context for value of estrogen in building muscle: http://forums.rxmuscle.com/showthrea...SERM+Llewellyn). Estrogen suppression can help to create a tighter look (e.g. for competition), but full suppression can produce too much dryness, including painful joints.
Generally speaking AI’s are not recommended for pre-menopausal women who are new to steroid cycling or using non-aromatizing compounds. If they choose to use an AI, it needs to be very conservatively used, as it is very easy to shut down estrogen with these compounds. The effects are similar to that noted above for long-term use of Nolvadex – hot flashes, etc.
[size=14pt]
Typical Use:
Primarily Nolvadex is used during the last 4-8 weeks of a contest prep to help reduce bodyfat in the hips / thighs / waist area. Again, it will not do the heavy lifting, but will support a tight contest prep. It is possible to experience either immediate interruption of menstrual flow, or breakthrough bleeding within 4 weeks of starting the cycle. Also once coming off, the effects will not be maintained and the estrogen-pattern bodyfat depositing will continue again. “Estrogen rebound” is often experienced as well, thus the taper down is recommended. Because of the potential of this rebound it is recommended to cycle Nolvadex with a specific end / target date in mind, followed by an expected rebound while your body recovers from the prep phase.
More aggressive aromatase inhibitors are not generally recommended unless you are an experienced cycler running aromatizing compounds such as NPP. If your cycle is intended for a bulker phase, then don’t use the AIs as you need the estrogen to build muscle mass and the water gain is minimal with most compounds women use.
Typical Cycle:
Nolvadex: 10- 20 mg per day, split in half AM and half PM for maximum of 8 weeks.
Arimidex: 0.5 mg EOD (only with an aromatizing AAS) for maximum of 6-8 weeks
AIs are very aggressive and will produce dry-feeling joints. If you experience aggressive hot/cold flashes and feeling sick, taper off over a couple days and stay off.
Aromasin: 25 mg EOD (only with an aromatizing AAS) for a maximum of 6-8 weeks
AIs are very aggressive and will produce dry-feeling joints. If you experience aggressive hot/cold flashes and feeling sick, taper off over a couple days and stay off.[/size]
By Sassy69
There are two classes of estrogen manipulators that often fall under the term “anti-estrogens”. The first are Selective Estrogen Receptor Manipulators (SERMs).
The only current example out there is Tamoxifen Citrate (brand name: Nolvadex). This operates specifically on the ovarian-driven estrogen process. The second category that falls under “anti-estrogens” are Aromatase Inhibitors (AI’s) that operate not on ovary-originating estrogen, but rather that resulting from aromatization (or conversion to estrogen) of testosterone. Examples of testosterones that convert are exogenous testosterones (anabolic androgenic steroids) such as Testosterone Propionate, Nandrolone Decoanate (“Deca”), or Dianabol (“d-bol”). There is also a natural source of androgen that converts to estrogen – that produced by the adrenal glands, in both men and women. When women enter menopause and their ovary-originating estrogen is no longer produced, the only remaining source of naturally produced estrogen is that resulting from the adrenals. Examples of AI’s are Arimidex, Aromasin and Letrozole. In practice, both these and Nolvadex, are all primarily prescribed as breast cancer treatment for post-menopausal women.
Women are more likely to use a SERM like Nolvadex to address the bodyfat associated with estrogen – specifically the stuff that tends to collect around the hips, thighs, lower abdomen and butt. It is important to note that each person has her own distribution of fat cells – estrogen tends to promote a higher concentration of fat cells in those lower areas as part of a natural preservation strategy to protect a fetus and also to provide an extra storage of energy source (bodyfat) to help support a growing fetus and the mother if there is any issue with available food sources (i.e. a drought scenario). This is by design and using an estrogen inibitor as a weight-loss strategy is not a good idea. Estrogen is one of the three basic hormones that make up who we are, and drive everything from moods to how we look and feel. Estrogen is there for a purpose and should not be completely suppressed only for the purpose of fat loss.
Nolvadex acts to fake out the estrogen receptors (envision a safety protector that you put into outlets as part of baby-proofing your house) and essentially cutting off the estrogen process, instead of literally turning it off. For cycle duration, it is recommended to keep it to 4-8 weeks maximum. Long-term use of Nolvadex has the potential to introduce health issues as described in this article: Side effects of long-term use of tamoxifen (http://www.livestrong.com/article/37...use-tamoxifen/). .In the extreme, full estrogen shut down in women can lead to what is often referred to as the “Female Athlete Triad” – basically estrogen shutdown as a result of an eating disorder such as anorexia, which leads to reduction in calcium, and eventually to brittle bones and a host of other issues related to a stopped period. Here is an overview of this particular issue: http://www.womenssportsfoundation.or...ick-Facts.aspx. Though this discussion is not focused on eating disorders, the end result, if someone decided to use medical estrogen suppression as a long-term weightloss protocol, is the same. This is just to reinforce that this is not a good idea.
The estrogen process tends to be fairly resilient so coming off a reasonable duration cycle can produce an estrogen rebound when the process is no longer inhibited. There isn’t much documentation about this rebound, but general guidance is to taper off a cycle by reducing the dose (e.g. in half, every 3 days).
In the context of this article, Aromatase Inhibitors are more specific to the estrogen produced as a result of using an aromatizing steroid. This means that the steroid cycle is more aggressive and will produce side effects such as water retention and potentially more mood swings, as the converted estrogen may be adding to natural estrogen levels, enhancing typical estrogen effects that might be experienced during a menstrual cycle. AI’s are more commonly used by men who cycle as the increase in estrogen can produce such side effects in men as gynocomastia (enlarged breast tissue), water retention, mood swings, etc. For men, as well as women, full estrogen suppression is not helpful if the goal is to build muscle as water (e.g. from estrogen) is needed to create a “growth environment” in the muscle. . (This article is more geared towards men and the use of AIs to prevent gynecomastia, it still gives some context for value of estrogen in building muscle: http://forums.rxmuscle.com/showthrea...SERM+Llewellyn). Estrogen suppression can help to create a tighter look (e.g. for competition), but full suppression can produce too much dryness, including painful joints.
Generally speaking AI’s are not recommended for pre-menopausal women who are new to steroid cycling or using non-aromatizing compounds. If they choose to use an AI, it needs to be very conservatively used, as it is very easy to shut down estrogen with these compounds. The effects are similar to that noted above for long-term use of Nolvadex – hot flashes, etc.
[size=14pt]
Typical Use:
Primarily Nolvadex is used during the last 4-8 weeks of a contest prep to help reduce bodyfat in the hips / thighs / waist area. Again, it will not do the heavy lifting, but will support a tight contest prep. It is possible to experience either immediate interruption of menstrual flow, or breakthrough bleeding within 4 weeks of starting the cycle. Also once coming off, the effects will not be maintained and the estrogen-pattern bodyfat depositing will continue again. “Estrogen rebound” is often experienced as well, thus the taper down is recommended. Because of the potential of this rebound it is recommended to cycle Nolvadex with a specific end / target date in mind, followed by an expected rebound while your body recovers from the prep phase.
More aggressive aromatase inhibitors are not generally recommended unless you are an experienced cycler running aromatizing compounds such as NPP. If your cycle is intended for a bulker phase, then don’t use the AIs as you need the estrogen to build muscle mass and the water gain is minimal with most compounds women use.
Typical Cycle:
Nolvadex: 10- 20 mg per day, split in half AM and half PM for maximum of 8 weeks.
Arimidex: 0.5 mg EOD (only with an aromatizing AAS) for maximum of 6-8 weeks
AIs are very aggressive and will produce dry-feeling joints. If you experience aggressive hot/cold flashes and feeling sick, taper off over a couple days and stay off.
Aromasin: 25 mg EOD (only with an aromatizing AAS) for a maximum of 6-8 weeks
AIs are very aggressive and will produce dry-feeling joints. If you experience aggressive hot/cold flashes and feeling sick, taper off over a couple days and stay off.[/size]
