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Compounds in this section are sometimes used to support AAS use in general. They cover a wide range of uses, and, as with most AAAS use, these are typically used for purposes which are off label. Therefore, information and actual studies are hard to obtain.
Compound Type Notes
Accutane Acne prevention. Do not give blood if using.
Albuteral β2-adrenergic receptor agonist Cutter
Arimidex (Anastrozole) AI, Reversible, non-steroidal Standard AI, FAQ.
Aromasin (Exemestane) AI, Irreversible, steroidal Take with fatty meal, not water soluble.
Bazedoxifene SERM Need usage info
Cabergoline Dopamine Receptor Agonists Anti-prolactin
Clenbuterol Sympathomimetic Amine Cutter, Detectable for 4 days, seperate doses by 3-4 hours
Cialis Helps blood flow
Clomid SERM Used for PCT
Cyclofenil SERM
Cytadren (Aminoglutethimide) AI, Irreversible, steroidal Has cortisol reducing effect
Dantrolene Muscle Relaxant May be able to help for DNP overdose
Dimethyl sulfoxide (DMSO) Possibly dangerous, controversial joint pain relief.
DNP (2,4-Dinitrophenol) Dinitrophenols Cutter (See Datrolene)
Ephedrine Sympathomimetic Amine Cutter, Can enflame prostate
ECA or EC Stack Ephedrine / Caffine / Asprin (Optional) Cutter
Fulvestrant AI, selective estrogen receptor down-regulator (SERD) No information on usage during cycles.
HCG Synthetic LH
Humog (hMG) LH and FSH
Letrozole AI, Reversible, non-steroidal Powerful AI
Liv 52 Liver Protection
Ostarine (Enobosarm) SARM
Pramipexole Dopamine Receptor Agonists Anti-prolactin
Lasofoxifene SERM Need Info
Raloxifene SERM Can treat some gyno from puberty
Melatonin Neurohormone Sleep regulation
Nolvadex (Tamoxifen) SERM Used for PCT, FAQ.
SINGULAIR (montelukast sodium) Leukast Can prevent respiratory weakness from Tren
Testolactone AI, Reversible, non-steroidal Old, weak AI
T4 (Thyroxine) Thyroid Hormone Precursor to T3
Toremifene SERM Used in PCT
T3 Thyroid Hormone Cutter
Triptorelin GnRH Agonist One shot PCT, with risk of infertility
TUDCA Liver Protection
UDCA (Ursodiol) Liver Protection
Viagara Helps blood flow
Aromatase Inhibitor (AI), Reversible, Non-steroidal -- These drugs inhibit aromatization by reversible competition for the aromatase enzyme. By using up the aromatase molecules in the system, it is unavailable to participate in the aromatization of Testosterone which greatly slows down the process.
Aromatase Inhibitor (AI), Irreversable, Steroidal -- These drugs form a permanent and deactivating bond with the aromatase enzyme. This prohibits the aromatase molecule from participating in the aromatization of testosterone.
Dinitrophenols -- A group of non-naturally occurring chemical compounds which are nitro derivatives of phenol.
Dopamine Receptor Agonists -- A chemical that binds to the dopamine receptor and triggers a response. Used to stop the production of prolactin.
GnRH Agonist (Gonadotropin-releasing Hormone Agonists) -- A synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, the release of the pituitary hormones FSH and LH.
Leukotriene Receptor Antagonist (Leukast) -- Block the actions of cysteinyl leukotrienes at the CysLT1 receptor on target cells such as bronchial smooth muscle.
SARMs (Selective Androgen Receptor Modulators) -- SARMs are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much more selective in their action, allowing them to be used for many more clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.
SERMs (Selective Estrogen Receptor Modulators) -- This class of drugs are estrogen antagonists and do not lower the amount of estrogen that is in the system; they act by binding to the estrogen receptor without generating a biological response. Different SERMs can block the estrogen receptors in different areas of the body. The ones listed block them in breast tissue.
Sympathomimetic Amine -- Sympathomimetic drugs mimic the effects of transmitter substances of the sympathetic nervous system. Amines are organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are derivatives of ammonia, wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group.
FAQ
Q: Can Nolvadex (Tamoxifene) and Arimidex (Anastrozole) be used together?
There is a lot of confusing information on wether or not these two compounds can be ran together. Looking at drug interaction charts, Medscape has the following:
tamoxifen + anastrozole
tamoxifen decreases levels of anastrozole by unspecified interaction mechanism. High likelihood serious or life-threatening interaction. Contraindicated unless benefits outweigh risks and no alternatives available. Never use combination. Anastrozole and tamoxifen should not be administered together.
This information has been contradited by a few studies.
www.ncbi.nlm.nih.gov
In conclusion, the results of this study confirm that anastrozole does not affect the pharmacokinetics of tamoxifen when the two drugs are given in combination to post-menopausal women with early breast cancer. In addition, the oestradiol suppressant effects of anastrozole appear unaffected by tamoxifen.
As a result of (a) the lack of effect of anastrozole on tamoxifen and DMT levels and (b) the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together.
The actual ATAC trial that this information comes from. Pharmacokinetic details can be found here
"...the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together."*
A: Taking arimidex with tamoxifen decreases the serum concentration of anastrozole by 27%, but has no effect on the pharmacodynamics of either
Q: Does Aromasin need to be taken with fat?
A: It works better when taken with a high fatty meal, yes.
www.rxlist.com
Exemestane is freely soluble in N, N-dimethylformamide, soluble in methanol, and practically insoluble in water
www.rxlist.com
the recommended dose of AROMASIN is 50 mg once daily after a meal.
www.drugs.com
High-fat meal increases plasma exemestane concentrations by approximately 40%.
Absorption: Following oral administration of radiolabeled exemestane, at least 42% of radioactivity was absorbed from the gastrointestinal tract. Exemestane plasma levels increased by approximately 40% after a high-fat breakfast.
www.drugs.com
Dosages >25 mg daily not shown to provide substantially greater suppression of plasma estrogens but may increase adverse effects
Compound Type Notes
Accutane Acne prevention. Do not give blood if using.
Albuteral β2-adrenergic receptor agonist Cutter
Arimidex (Anastrozole) AI, Reversible, non-steroidal Standard AI, FAQ.
Aromasin (Exemestane) AI, Irreversible, steroidal Take with fatty meal, not water soluble.
Bazedoxifene SERM Need usage info
Cabergoline Dopamine Receptor Agonists Anti-prolactin
Clenbuterol Sympathomimetic Amine Cutter, Detectable for 4 days, seperate doses by 3-4 hours
Cialis Helps blood flow
Clomid SERM Used for PCT
Cyclofenil SERM
Cytadren (Aminoglutethimide) AI, Irreversible, steroidal Has cortisol reducing effect
Dantrolene Muscle Relaxant May be able to help for DNP overdose
Dimethyl sulfoxide (DMSO) Possibly dangerous, controversial joint pain relief.
DNP (2,4-Dinitrophenol) Dinitrophenols Cutter (See Datrolene)
Ephedrine Sympathomimetic Amine Cutter, Can enflame prostate
ECA or EC Stack Ephedrine / Caffine / Asprin (Optional) Cutter
Fulvestrant AI, selective estrogen receptor down-regulator (SERD) No information on usage during cycles.
HCG Synthetic LH
Humog (hMG) LH and FSH
Letrozole AI, Reversible, non-steroidal Powerful AI
Liv 52 Liver Protection
Ostarine (Enobosarm) SARM
Pramipexole Dopamine Receptor Agonists Anti-prolactin
Lasofoxifene SERM Need Info
Raloxifene SERM Can treat some gyno from puberty
Melatonin Neurohormone Sleep regulation
Nolvadex (Tamoxifen) SERM Used for PCT, FAQ.
SINGULAIR (montelukast sodium) Leukast Can prevent respiratory weakness from Tren
Testolactone AI, Reversible, non-steroidal Old, weak AI
T4 (Thyroxine) Thyroid Hormone Precursor to T3
Toremifene SERM Used in PCT
T3 Thyroid Hormone Cutter
Triptorelin GnRH Agonist One shot PCT, with risk of infertility
TUDCA Liver Protection
UDCA (Ursodiol) Liver Protection
Viagara Helps blood flow
Aromatase Inhibitor (AI), Reversible, Non-steroidal -- These drugs inhibit aromatization by reversible competition for the aromatase enzyme. By using up the aromatase molecules in the system, it is unavailable to participate in the aromatization of Testosterone which greatly slows down the process.
Aromatase Inhibitor (AI), Irreversable, Steroidal -- These drugs form a permanent and deactivating bond with the aromatase enzyme. This prohibits the aromatase molecule from participating in the aromatization of testosterone.
Dinitrophenols -- A group of non-naturally occurring chemical compounds which are nitro derivatives of phenol.
Dopamine Receptor Agonists -- A chemical that binds to the dopamine receptor and triggers a response. Used to stop the production of prolactin.
GnRH Agonist (Gonadotropin-releasing Hormone Agonists) -- A synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, the release of the pituitary hormones FSH and LH.
Leukotriene Receptor Antagonist (Leukast) -- Block the actions of cysteinyl leukotrienes at the CysLT1 receptor on target cells such as bronchial smooth muscle.
SARMs (Selective Androgen Receptor Modulators) -- SARMs are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much more selective in their action, allowing them to be used for many more clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.
SERMs (Selective Estrogen Receptor Modulators) -- This class of drugs are estrogen antagonists and do not lower the amount of estrogen that is in the system; they act by binding to the estrogen receptor without generating a biological response. Different SERMs can block the estrogen receptors in different areas of the body. The ones listed block them in breast tissue.
Sympathomimetic Amine -- Sympathomimetic drugs mimic the effects of transmitter substances of the sympathetic nervous system. Amines are organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are derivatives of ammonia, wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group.
FAQ
Q: Can Nolvadex (Tamoxifene) and Arimidex (Anastrozole) be used together?
There is a lot of confusing information on wether or not these two compounds can be ran together. Looking at drug interaction charts, Medscape has the following:
tamoxifen + anastrozole
tamoxifen decreases levels of anastrozole by unspecified interaction mechanism. High likelihood serious or life-threatening interaction. Contraindicated unless benefits outweigh risks and no alternatives available. Never use combination. Anastrozole and tamoxifen should not be administered together.
This information has been contradited by a few studies.
The effect of anastrozole on the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer
Thirty-four post-menopausal women with early breast cancer who had received 20 mg tamoxifen once daily as adjuvant therapy for at least 10 weeks participated in a randomized, double-blind, parallel-group, multicentre trial. The primary aim of the trial ...
www.ncbi.nlm.nih.gov
In conclusion, the results of this study confirm that anastrozole does not affect the pharmacokinetics of tamoxifen when the two drugs are given in combination to post-menopausal women with early breast cancer. In addition, the oestradiol suppressant effects of anastrozole appear unaffected by tamoxifen.
As a result of (a) the lack of effect of anastrozole on tamoxifen and DMT levels and (b) the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together.
The actual ATAC trial that this information comes from. Pharmacokinetic details can be found here
"...the observed fall in blood anastrozole levels having no significant effect on oestradiol suppression by anastrozole, we conclude that the observed reduction in anastrozole levels by tamoxifen is unlikely to be of clinical significance when anastrozole and tamoxifen are administered together."*
A: Taking arimidex with tamoxifen decreases the serum concentration of anastrozole by 27%, but has no effect on the pharmacodynamics of either
Q: Does Aromasin need to be taken with fat?
A: It works better when taken with a high fatty meal, yes.
Aromasin (Exemestane): Side Effects, Uses, Dosage, Interactions, Warnings
Aromasin (Exemestane) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
Exemestane is freely soluble in N, N-dimethylformamide, soluble in methanol, and practically insoluble in water
Aromasin (Exemestane): Side Effects, Uses, Dosage, Interactions, Warnings
Aromasin (Exemestane) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
the recommended dose of AROMASIN is 50 mg once daily after a meal.
Exemestane Monograph for Professionals - Drugs.com
Exemestane reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).
www.drugs.com
High-fat meal increases plasma exemestane concentrations by approximately 40%.
Absorption: Following oral administration of radiolabeled exemestane, at least 42% of radioactivity was absorbed from the gastrointestinal tract. Exemestane plasma levels increased by approximately 40% after a high-fat breakfast.
Exemestane Monograph for Professionals - Drugs.com
Exemestane reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).
www.drugs.com
Dosages >25 mg daily not shown to provide substantially greater suppression of plasma estrogens but may increase adverse effects
