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HGH - ED vs EOD
"A very thorough well controlled 4 year study published in The Journal of Clinical Endocrinology & Metabolism Vol. 87, No.8 3573-3577 clearly shows every other day (EOD) hGH injections to be much more beneficial in the long run to everyday injections. Everyday injections seems to drastically lower your body's sensitivity to it's own GH secretion. The study included children with idiopathic short stature, but can be ever casting on us, normal non-deficient hGH individuals who may use hGH periodically for bodybuilding, sports and health purposes.
The 38 children were divided into 2 groups:
Group I received daily hGH injections.
Group II received alternate day hGH injections.
It is important to note that the total weekly dosage of hGH was the same for both groups.
Both groups received the hGH therapy contiguously for 2 years. Their natural growth was followed for an additional 2 years after hGH therapy ended. They were all measured at 3-month intervals during the 4 years period (2 years with hGH therapy and 2 years after). Their serum GH was measured by double antibody RIA kit.
During hGH therapy, both groups accelerated their growth substantially. Group I receiving the daily hGH injections first and second year velocity was 3.4 and 2.3 superdrol Group II receiving the alternate hGH inj. had 3.0 and 2.0 SD for first and second year respectively.
Over the initial 6 months after withdrawal of therapy, growth velocity decelerated to a low nadir -3.9 superdrol score for the daily therapy group, whereas it decelerated in the alternate day group to only -0.2 SD score.
During the 2 years off therapy, the later group (taking EOD injections)
maintained growth rates of -0.2 to -1.2 superdrol score, which is similar to their SD score prior to the hGH treatment. The daily group also recovered but very slowly, on the fourth semiannual evaluation off therapy. The cumulative 4-year growth velocity (2yrs on and 2 yrs off therapy) of the alternate day group was greater than that of the daily therapy group (mean, 0.9 vs. 0.3 SD score).
At the end of the 4-yr therapy period, the adult height prediction of the alternate day group was greater than that of the daily group by a mea of 6.5cm (that's over 2.5" in height, quite a lot of difference).
In even simpler English, to translate what it may mean to us is that using hGH every day will only negligibly give better short-term results. Yet using alternate day hGH will give radically better long-term results and much better recovery. As the body may get back to homeostasis much faster.
Remember the two groups got the same weekly total hGH dosage, so your every other day hGH injections would be twice as if you used it every day.
The researchers said the dose was of less impotency than the schedule of the injections. Daily hGH therapy for 3 years caused subnormal growth persisting for 1.5 years (very bad)
It may be that the problem is not enough hGH or IGF-1 secretion but rather
the body's decreased sensitivity to it. The interesting part is that the serum GH levels and serum IGF-I and IGF-binding protein remained unaffected or relatively mutely affected. Even your body's endogenous pulsatile secretion of GH resumes within just days even after long-term hGH therapy.
The researchers hypothesis is that the tolerance may be in the "GH signal transduction in selective target organs in response to the disappearance of the unique pulsatile pattern of serum GH during GH therapy". You see, hGH taken via sc injections do not imitate the your body's own GH secretion. "Indeed, daily sc administration of GH results in an unphysiological serum GH profile, with peak levels at 4 h and a slow decline over the course of the following 12–24 h. This pattern can be regarded as continuous administration, rather than the physiological GH pulses, with a frequency of about eight per day."
"Assuming that the withdrawal syndrome is related to tolerance that might have developed toward hGH or IGF-I, we tried to prevent it by alternate day treatment. Moreover, hGH doses used in therapy often stimulate IGF-I to supraphysiological serum levels, suggesting that target tissues IGF-I may also be higher than normal. The mechanism seems, therefore, to rest with hGH and IGF-I action at their target tissues. We now show that alternate day therapy with hGH in children with an intact GH-IGF-I axis prevents the withdrawal syndrome"
Researchers mark the analogy to another endocrine tolerance and withdrawal syndrome: "alternate day therapy with glucocoricoids prevents tolerance to that hormone to a substantial degree, "Interestingly, glucocoricoids withdrawal syndrome can also occur while the hypothalamic-pituitary-adrenal axis is intact (8), indicating that tolerance to glucocoricoids has developed
at the target organ level (9)."
"A very thorough well controlled 4 year study published in The Journal of Clinical Endocrinology & Metabolism Vol. 87, No.8 3573-3577 clearly shows every other day (EOD) hGH injections to be much more beneficial in the long run to everyday injections. Everyday injections seems to drastically lower your body's sensitivity to it's own GH secretion. The study included children with idiopathic short stature, but can be ever casting on us, normal non-deficient hGH individuals who may use hGH periodically for bodybuilding, sports and health purposes.
The 38 children were divided into 2 groups:
Group I received daily hGH injections.
Group II received alternate day hGH injections.
It is important to note that the total weekly dosage of hGH was the same for both groups.
Both groups received the hGH therapy contiguously for 2 years. Their natural growth was followed for an additional 2 years after hGH therapy ended. They were all measured at 3-month intervals during the 4 years period (2 years with hGH therapy and 2 years after). Their serum GH was measured by double antibody RIA kit.
During hGH therapy, both groups accelerated their growth substantially. Group I receiving the daily hGH injections first and second year velocity was 3.4 and 2.3 superdrol Group II receiving the alternate hGH inj. had 3.0 and 2.0 SD for first and second year respectively.
Over the initial 6 months after withdrawal of therapy, growth velocity decelerated to a low nadir -3.9 superdrol score for the daily therapy group, whereas it decelerated in the alternate day group to only -0.2 SD score.
During the 2 years off therapy, the later group (taking EOD injections)
maintained growth rates of -0.2 to -1.2 superdrol score, which is similar to their SD score prior to the hGH treatment. The daily group also recovered but very slowly, on the fourth semiannual evaluation off therapy. The cumulative 4-year growth velocity (2yrs on and 2 yrs off therapy) of the alternate day group was greater than that of the daily therapy group (mean, 0.9 vs. 0.3 SD score).
At the end of the 4-yr therapy period, the adult height prediction of the alternate day group was greater than that of the daily group by a mea of 6.5cm (that's over 2.5" in height, quite a lot of difference).
In even simpler English, to translate what it may mean to us is that using hGH every day will only negligibly give better short-term results. Yet using alternate day hGH will give radically better long-term results and much better recovery. As the body may get back to homeostasis much faster.
Remember the two groups got the same weekly total hGH dosage, so your every other day hGH injections would be twice as if you used it every day.
The researchers said the dose was of less impotency than the schedule of the injections. Daily hGH therapy for 3 years caused subnormal growth persisting for 1.5 years (very bad)
It may be that the problem is not enough hGH or IGF-1 secretion but rather
the body's decreased sensitivity to it. The interesting part is that the serum GH levels and serum IGF-I and IGF-binding protein remained unaffected or relatively mutely affected. Even your body's endogenous pulsatile secretion of GH resumes within just days even after long-term hGH therapy.
The researchers hypothesis is that the tolerance may be in the "GH signal transduction in selective target organs in response to the disappearance of the unique pulsatile pattern of serum GH during GH therapy". You see, hGH taken via sc injections do not imitate the your body's own GH secretion. "Indeed, daily sc administration of GH results in an unphysiological serum GH profile, with peak levels at 4 h and a slow decline over the course of the following 12–24 h. This pattern can be regarded as continuous administration, rather than the physiological GH pulses, with a frequency of about eight per day."
"Assuming that the withdrawal syndrome is related to tolerance that might have developed toward hGH or IGF-I, we tried to prevent it by alternate day treatment. Moreover, hGH doses used in therapy often stimulate IGF-I to supraphysiological serum levels, suggesting that target tissues IGF-I may also be higher than normal. The mechanism seems, therefore, to rest with hGH and IGF-I action at their target tissues. We now show that alternate day therapy with hGH in children with an intact GH-IGF-I axis prevents the withdrawal syndrome"
Researchers mark the analogy to another endocrine tolerance and withdrawal syndrome: "alternate day therapy with glucocoricoids prevents tolerance to that hormone to a substantial degree, "Interestingly, glucocoricoids withdrawal syndrome can also occur while the hypothalamic-pituitary-adrenal axis is intact (8), indicating that tolerance to glucocoricoids has developed
at the target organ level (9)."
