How to Buy BPC 157

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BPC 157 has generated a great deal of interest in research circles in recent years. This naturally occurring peptide, originally isolated from human gastric contents, has significant healing properties. Research shows that BPC 157 can promote musculoskeletal repair, improve blood vessel growth, and stimulate neurological activity. The peptide has been extensively investigated for its ability to promote healing in gastrointestinal disorders like Crohn’s disease, ulcerative colitis, and fistulas.

Individuals who want to buy BPC 157 for research purposes are generally interested in finding the highest quality peptide at the most affordable price. Below is a look at BPC 157 for sale, the benefits that BPC 157 has in research, and dosing protocols for studies.

How to Buy BPC 157​

BPC 157 can be purchased from a number of suppliers on the internet, but not all providers offer the same quality, purity, or guarantee to back the product. In research, starting off with a pure product is necessary to ensure that the results of a study are due to the agent being studied and not a result of contamination or, in some cases, adulteration like adding fillers, binding agents and TFA. Finding BPC 157 for sale on the internet is easy enough. Finding a reputable BPC 157 source, however, requires due diligence.

Evaluating the sources from which you purchase peptides like BPC 157 can be a challenge. Some good places to start include the quality of the website, the information provided by the manufacturer, and reviews of previous customers as well as the company’s response to them.

For instance, if you find BPC 157 on sale on a website with poor grammar and broken links, you may want to think twice about purchasing from that supplier. After all, the quality of a website is, today, the equivalent of cleanliness in a restaurant. Would you eat at a place with dirty tables, misspellings on the menu, and flies on the dishes? And if you did, would you expect that place to provide you with the highest quality, most nutritious, purest food?

When it comes to information, the basics about the peptide should be the minimum a website offers. In the case of BPC 157, basic information would look something like the following.



Amino Acid Sequence: GEPPPGKPADDAGLV
Chemical Formula: C62H98N16O22
Molecular Weight: 1419.5 g/mol
PubChem CID: 9941957
CAS No: 137525-51-0
Synonyms: Bepecin, PL-14736, PLD-116, Body Protection Compound 15



Source: PubChem


The information above can help you, as a buyer, to confirm if the peptide the company is selling is, in fact, the peptide you are interested in buying. Objective details, like the CAS number of molecular formula of the peptide can help you to ensure that the company, at the very least, isn’t confusing the peptide you are interested in with some other chemical compound.

Another good way to evaluate the quality of a peptide seller is to look at the claims being made on the website. Are the claims in keeping with established science on the topic or do they stray into territory for which there is either no research or contradictory research? More importantly, does the website reference reliable studies that you can look up and verify on your own? A company that takes the time to discuss and reference the science behind its products is likely more committed to quality and accuracy than one that makes spurious claims about what a product can provide.

In addition to the above objective information, the website should also list the purity of the peptide and evidence to back it up. You want to see things like HPLC analyses and/or mass spectrometry results. These details tell you that the company backs up its products with real scientific methods of validation.

Customer Reviews about BPC 157​

Customer reviews can be a potent weapon in the arsenal of would-be buyers, but everyone knows that reviews can be bought, hacked, programmed, and manipulated to produce false results. How, then, does one tell if the customer reviews about BPC 157 are real or not?

For starters, you want to look for details. People who have used a product should speak about specific aspects of it. In the case of BPC 157, reviews may reference the packaging, the quality of the containers, the effects of the peptide, or the shelf-life. Look for words that relate to BPC 157 specifically, such as “healing” or “tendon.” The more specific the words in the review, the more likely it is to be true.

Another way to spot a fake is to look at the pronouns. Fake reviews tend to use more first-person pronouns than real reviews. Words like “I” and “me” can be problematic if they occur too often. Remember, the review is about the product, not about the person who purchased it[1], [2].

BPC 157 Arginate vs BPC 157 Acetate​

Another way to evaluate the quality of a BPC 157 source is to look at whether the seller understands the difference between the arginate and acetate versions of the peptide. BPC 157 acetate is a slightly modified version of the natural peptide that provides for increased shelf-life and better resistance to the extremes of shipping environments. BPC 157 acetate is commonly used for subcutaneous injection as it is degraded in the GI tract to such an extent that nearly 98% of it is gone after just a short time in gastric acid.

For researchers interested in understanding the effects of oral administration of BPC 157, then the arginate salt is preferred. BPC 157 arginate retains the superior shipping and storage properties of BPC 157 acetate, but is also stable in gastric acid for extended periods. Research shows that just 10% of BPC 157 arginate is degraded after 5 hours in gastric acid.

BPC 157 arginate is sometimes referred to as “stable BPC 157.” This is a correct usage of the term stable, but it is important for anyone looking to buy BPC 157 that they specify whether the seller is referring to BPC 157 arginate or acetate as the two peptides are both “stable” depending on context.

What Is BPC 157?​

If you are looking to purchase BPC 157, you likely already know what the peptide is and the research that has been done on it. Still, it is important to cover this topic broadly so that you can evaluate whether the BPC 157 source you are considering buying BPC 157 from is reliable or not.

BPC 157 is a synthetically produced peptide based off of the naturally occurring body protection compound (BPC) protein that was isolated from human gastric contents. This short peptide has been shown to have both anti-inflammatory and wound healing effects not just in the gastrointestinal system, but in musculoskeletal and neurological tissue as well. BPC 157 also promotes the growth of blood vessels and is thought to help maintain homeostasis.

Research on BPC 157 has focused primarily on its wound healing properties. It has undergone phase 1 clinical trials and has been investigated as a potential treatment for tendon injury, inflammatory bowel disease, and accelerating the rate of fistula healing.

BPC 157 Benefits​

Understanding what BPC 157 does is important to developing research protocols for examining BPC 157 benefits. Research in mice has revealed that BPC 157 accelerates the growth of fibroblasts, the cells responsible for wound repair in many tissues. In order for fibroblasts to fulfill their purpose, they must go through three phases of development: outgrowth from stem cells, survival in the blood stream and tissues, and migration to the area of repair. Research shows that BPC 157 promotes each of these stages of the fibroblast life cycle and thus improves wound healing as a result of increasing fibroblast quantity and health[3].

It isn’t simply the speed of repair that BPC 157 benefits. Research in mice shows that BPC 157 can actually improve the overall quality of the repair, leading to less joint contracture, improved muscle motor function, and better functional outcomes (e.g. preserved walking pattern, preserved range of motion)[4].

Interestingly, some BPC 157 benefits may be mediated through its ability to increase growth hormone (GH) receptor expression on fibroblasts. It has long been known that GH can increase rates of wound repair, particularly in musculoskeletal tissue, but use of the hormone for this purpose has been limited by side effects. The ability to selectively increase the number of GH receptors on fibroblasts provides the same wound healing benefits as increasing GH levels, but without the side effects[5].

Another interesting benefit of BPC 157 is its ability to increase levels of vascular endothelial growth factor (VEGF). VEGF is a potent stimulator of blood vessel growth, but it is generally only expressed by cells suffering from oxygen deprivation. BPC 157 is able to induce VEGF without oxygen deprivation, thereby accelerating blood vessel growth without impacting tissue health. The result is an increased supply of blood, particularly to areas of tissue damage, that brings with it the necessary nutrients and cells to promote healing[6], [7].

BPC 157 has even been used in the setting of traumatic brain injury. As it turns out, BPC 157 is unique is that it promotes tissue repair without increasing inflammation. Most wound healing agents have been shown to boost inflammatory signals because they invoked bits and pieces of the body’s natural immune response. BPC 157 is different because it directly affects the cells involved in wound healing, driving tissue repair without increasing inflammatory immune responses. Dr. Samantha Wilson (School of Mechanical, Electrical and Manufacturing Engineering at Loughborough University) works with BPC 157 in the treatment of traumatic brain injury. She believes there may be some application for BPC-157 in a broader scope and in conjunction with other treatments as a means of stimulating stem cell differentiation and neuron regrowth in damaged brains, thus helping people to regain lost skills such as speech, walking, or even sight.

BPC 157 and Leaky Gut Syndrome​

Though leaky guy syndrome sounds like something a fifth grader invented to avoid picture day, it is actually a legitimate condition that has taken the medical community decades to recognize as something more than simple hypochondriasis.

The lining of the intestine is so finely constructed and complex that if were to be stretched out it would cover more than 4,000 square feet or roughly twice the square footage of the average American home. This much absorptive area is folded and stuffed within the average human body and is held together by a specific form of protein called a tight junction. In a healthy gut, the things you consume (both intentional and otherwise) are selectively allowed to pass through this barrier both to ensure proper absorption of nutrients and to keep harmful substances at bay. When this barrier breaks down, it can lead to inflammation and serious disease.

Researchers have long known that increased intestinal permeability (i.e., leaky gut) is a pathological component of diseases like inflammatory bowel disease and celiac sprue. Recently, however, researchers have begun to suspect that leaky guy may, in fact, be a component of everything from lupus to asthma to acne to fibromyalgia[8]. Thus, there has been a great deal of interest in finding a treatment of leaky gut with the hope that it may put an end to the ever-increasing prevalence of a number of life-altering autoimmune diseases.

Of course, this has led to renewed interest in BPC 157 not just as a treatment of leaky gut syndrome, but as a means of exploring the complex processes that help to maintain intestinal barrier function. Recent research suggests that BPC 157 is an effective preventative against and treatment for leaky gut syndrome[9].

The interesting thing is that BPC 157 appears to protect all cells from the kind of damage that can lead to leaky gut. In other words, it doesn’t just protect gastric endothelial cells, but rather protects all endothelium including that of blood vessels. Thus, BPC 157 may not only prevent leaky gut syndrome, it may actually protect blood vessels and other endothelial surfaces as well. In the case of blood vessels, scientists are interested in how BPC 157 may be able to prevent plaque build-up in arteries and stabilize the body in the setting of trauma and infection by mitigating the effects of devastating clotting disorders like disseminated intravascular coagulation and thrombocytopenia.

How to Use BPC 157​

BPC 157 is relatively straightforward to use, though how it is administered will depend primarily on the type of BPC 157 in question. BPC 157 acetate is best administered via injection while BPC 157 arginate can be administered orally. Obviously, the latter has the advantage in terms of ease of administration, particularly in animal studies. It is worth noting, however, that injection of the acetate salt ensures a specific dose is administered and thus may provide a more accurate result depending on the study design. BPC 157 can also be administered via patch, suppository, cream, or sublingual tablet but these forms of delivery are relatively rare.

In animal studies, BPC 157 research dosing is usually on the order of 10 mcg/kg. Of course, the bulk of these animal studies were done in rodents and dosing does not directly translate by mass to some other organisms. Research in pigs or primates, for instance, would generally start at around 1.5 micrograms per kilogram.

In a 2015 pilot study, BPC 157 was tested in 42 healthy human participants. The peptide was administered orally in the form of a tablet at doses of 0.25, 0.5, 1, and 2 mcg/kg in a 2015 clinical trial[10]. For the average person at 75 kg, this puts the dosage in the range of 18.75 mcg to 150 micrograms. Note that doses as high as 1 gram have been administered in less controlled settings with no notable side effects. Keep in mind that the best approach, particularly for researchers new to BPC 157, is to use the lowest dose that will achieve the desired effect. Thus, for the treatment of local wound healing, for instance, a much lower dose could be used than if systemic effects were being sought such as in the treatment of inflammatory bowel disease.

A BPC 157 dosage calculator can be useful in converting doses for various formats. The dosages in the 2015 clinical trial above are for oral administration. Injected BPC 157 can generally be administered at a lower dose, particularly if the research is focused on BPC 157 benefits in local healing as opposed to systemic outcomes. Keep in mind that there are differences in absorption rate and thus peptide half-life in the bloodstream when BPC 157 is administered orally versus by injection. This does not necessarily translate to different outcomes, but should be considered when attempting to create experimental protocols.

BPC 157 Oral Bioavailability​

For researchers concerned about mode of delivery, it is worth pointing out that several studies have indicated that BPC 157 is as potent in its oral forms as it is in its injected forms. This is rare not just for peptides, but for medications and drugs in general. In a 2010 study looking at ligament healing in rats given BPC 157, researchers found that the peptide is as effective when administered orally or topically as it is when injected[11].

It is worth noting that there is likely a difference in the total amount of BPC 157 that enters the bloodstream in these various modes of administration. This suggests that the peptide is effective at multiple doses and peak concentrations. This further supports that caution above that the lowest effective dose should be used to avoid complications but also to reduce total cost and prolong supply.

Best Place to Buy BPC 157​

Where you choose to purchase BPC 157 will ultimately come down to preference, location, and speed of delivery. For the scientific minded, Peptide Sciences offers concise technical information about the peptides it sells along with robust analysis of purity and quality. Few companies are as devoted to providing their customers with every shred of data available on their products as Peptide Sciences, which goes to great lengths to investigate the biomedical research behind the research products it offers.

The transparency doesn’t end simply at technical and scientific data, however. Peptide Sciences also offers clear cost information that is front and center for all of its products. There is no guessing about quantity, quality, or cost with Peptide Sciences.