I was using 4x200mg Ibuprofen every 6 hours around the clock for a couple of months. This was for some persistent swelling and pain from a wrist I broke when I totalled my car. I stopped taking it because of some serious edema in my feet, calves, and even in my stomach. Stopping the ibuprofen, flushing my body with lasix, potassium and reasonably large anounts of water resolved the issue.
My working assumption (just that, an assumption) is that if you're doing liver damage you're going to notice some other stuff as well (maybe lethargy etc.) but this isn't failproof.
I was told by my hand pain specialist that the dose of ibuprofen I was on was the max and that staying at that dose for 2-3 years I might start to see some issues.
You can try to mix stuff up periodically like with Aleve, and cycle on/off esomeprozole to protect your stomach (unless you do sublingual / injectable B12 in which case you could just stay on it for the duration).