Ok so it seems like a lot of guys are starting to use methylated orals as part of their cycle, weather its as a front end load for quick mass or as a backload to you blast. Regardless of where in your cycles you take them it is VERY IMPORTANT that you take simple steps to reduce the risk of liver failure-IMO if you are taking orals and not taking liver care products you need to do some more research!
There are many types of liver injury, but only one is normally associated with the use of oral androgens -- cholestasis. This condition is defined as a failure of normal bile to reach the duodenum, which may be due to a number of different pathological states between the hepatocyte and the ampulla of Vater. When one takes oral androgens (typically methylated at C17a) the physical structure of the hepatocyte is altered -- microfilaments and canaliculi become less contractile. Disruptions in the canalicular bile salt export pump may also occur. This leads to impaired bile flow and the retention of highly cytotoxic hydrophobic bile salts. At low concentrations, these retained bile salts cause apoptosis; at higher concentrations, necrosis and severe liver damage.
Orals are great products that can provide decent gains but be smart.
I gathered a few descriptions of the what I feel you should be taking...
Tauroursodeoxycholic acid:
Tauroursodeoxycholic acid (TUDCA) is a liver aid introduced as a supplement by ThermoLife in their product Liver Longer. It looks like a good resource for preventing cholestasis, one of the major risks with 17 alkylated steroids. Tauroursodeoxycholic acid is an anti-cholestatic agent, modulating protein kinase C (PKC) pathway. PKC reduces ischemic damage in several organs. Its isoform modulates ezrin, a key protein in the maintenance of cell lamellipoidal extensions.
TUDCA, a metabolite to UDCA (Ursodeoxycholic acid), is basically a particular Bile Acid enzyme that is naturally produced in the Liver. TUDCA has been proven in over 220 documented cases to dramatically improve both the performance of the liver as well as decrease pre-existing damage. TUDCA (Liver Longer) reduces the enzymatic stress on the liver. TUDCA/UDCA has been proven in double-blind study's to reduce enzymatic stress caused by methylation by an average of 41%.
A multicenter, cooperative study involving 12 hospitals throughout Italy evaluated the effects of long-term oral administration of TUDCA (500 mg/d for 3 months) on serum liver enzymes, total bilirubin, and serum lipid levels in patients with biopsy-proven chronic hepatitis due to hepatitis C virus (HCV) or hepatitis B virus (HBV) infection.
TUDCA was well tolerated and safe and was associated with a significant (P < 0.001) decrease in all serum liver enzyme levels. A slight improvement in total bilirubin levels was also observed. In addition, TUDCA caused a slight but significant improvement in serum lipid profiles.
These favorable changes were similar in HCV and HBV hepatitis and were independent of age, sex, body weight, and alcohol consumption. These results indicate TUDCA may have a place in the treatment of patients with chronic hepatitis, a possibility that needs to be verified by means of long-term, prospective, placebo-controlled, double-blind studies
Milk Thistle
The antioxidant milk thistle has been used since Greco-Roman times to treat an array of liver ailments. Several studies suggest milk thistle protects the liver from damaging toxins such as alcohol and certain drugs. The active component most responsible for milk thistles detoxifying effects is called silymarin. This substance, comprised of several flavonolignands, helps repair liver cells damaged by toxins as well as protecting healthy liver cells. It has also been purported to have cholesterol lowering benefits as well.
N-Acetyl-L-Cysteine (NAC)
NAC, arguably the pinnacle antioxidant, consists of the amino acid cysteine joined with an acetyl group making it more soluble and more biovailable than L-Cysteine alone. NAC , basically a precursor to glutathione, donates cystiene to form glutathione which is found in the body and produced in the liver. NAC has been shown in studies to prevent cell death.
Alpha Lipoic Acid (ALA)
Alpha Lipoic Acid is quite possibly the most novel, multifaceted, and important antioxidants available today. It neutralizes free radicals in both the aqueous and lipid portions of cells, is a key player in the synergism of other antioxidants extending the metabolic life of glutathione and Coenzyme Q-10, repairs liver damage, has blood lipid modulating properties lowering risk factors associated with cardiovascular disease (CVD), and enhances insulin function speeding the removal of glucose from the bloodstream and ushering it into muscles.
Beta-Sitosterol
Beta-Sitosterol is one of many phytosterols, phytochemicals naturally occurring in plants, whose structure closely resembles cholesterol. It has been shown to significantly lower cholesterol and has been used to treat hypercholesterolemia. Its major mechanisms of action are thought to be by preventing the absorption of dietary fat in the intestines where fat is digested and by increasing the flow of cholesterol binding bile acids in the digestive track excreting it in the feces. Beta-Sitosterol has also been proven effective in many studies in treating BPH (benign prostatic hypertrophy).
Saw Palmetto
Rich in phytosterols and fatty acids, Saw Palmetto has been used in treating BPH as well as male pattern baldness. This is largely due to its supposed ability to inhibit 5-alpha reductase, an enzyme responsible for converting precious testosterone into DHT, and interfering with DHTs binding ability to androgen receptors.
Quercitin
A highly active flavonoid, Quercitin, is yet another fierce antioxidant scavenging free radicals within the body. It most notably improves cardiovascular function by preventing the oxidation of LDL thus lowering cholesterol, lowering blood pressure, and also possesses anti-inflammatory properties.
Please note that I'm not a doctor or a writer this is only my opinion and the opinion of the sites I cut and pasted info from🙂
There are many types of liver injury, but only one is normally associated with the use of oral androgens -- cholestasis. This condition is defined as a failure of normal bile to reach the duodenum, which may be due to a number of different pathological states between the hepatocyte and the ampulla of Vater. When one takes oral androgens (typically methylated at C17a) the physical structure of the hepatocyte is altered -- microfilaments and canaliculi become less contractile. Disruptions in the canalicular bile salt export pump may also occur. This leads to impaired bile flow and the retention of highly cytotoxic hydrophobic bile salts. At low concentrations, these retained bile salts cause apoptosis; at higher concentrations, necrosis and severe liver damage.
Orals are great products that can provide decent gains but be smart.
I gathered a few descriptions of the what I feel you should be taking...
Tauroursodeoxycholic acid:
Tauroursodeoxycholic acid (TUDCA) is a liver aid introduced as a supplement by ThermoLife in their product Liver Longer. It looks like a good resource for preventing cholestasis, one of the major risks with 17 alkylated steroids. Tauroursodeoxycholic acid is an anti-cholestatic agent, modulating protein kinase C (PKC) pathway. PKC reduces ischemic damage in several organs. Its isoform modulates ezrin, a key protein in the maintenance of cell lamellipoidal extensions.
TUDCA, a metabolite to UDCA (Ursodeoxycholic acid), is basically a particular Bile Acid enzyme that is naturally produced in the Liver. TUDCA has been proven in over 220 documented cases to dramatically improve both the performance of the liver as well as decrease pre-existing damage. TUDCA (Liver Longer) reduces the enzymatic stress on the liver. TUDCA/UDCA has been proven in double-blind study's to reduce enzymatic stress caused by methylation by an average of 41%.
A multicenter, cooperative study involving 12 hospitals throughout Italy evaluated the effects of long-term oral administration of TUDCA (500 mg/d for 3 months) on serum liver enzymes, total bilirubin, and serum lipid levels in patients with biopsy-proven chronic hepatitis due to hepatitis C virus (HCV) or hepatitis B virus (HBV) infection.
TUDCA was well tolerated and safe and was associated with a significant (P < 0.001) decrease in all serum liver enzyme levels. A slight improvement in total bilirubin levels was also observed. In addition, TUDCA caused a slight but significant improvement in serum lipid profiles.
These favorable changes were similar in HCV and HBV hepatitis and were independent of age, sex, body weight, and alcohol consumption. These results indicate TUDCA may have a place in the treatment of patients with chronic hepatitis, a possibility that needs to be verified by means of long-term, prospective, placebo-controlled, double-blind studies
Milk Thistle
The antioxidant milk thistle has been used since Greco-Roman times to treat an array of liver ailments. Several studies suggest milk thistle protects the liver from damaging toxins such as alcohol and certain drugs. The active component most responsible for milk thistles detoxifying effects is called silymarin. This substance, comprised of several flavonolignands, helps repair liver cells damaged by toxins as well as protecting healthy liver cells. It has also been purported to have cholesterol lowering benefits as well.
N-Acetyl-L-Cysteine (NAC)
NAC, arguably the pinnacle antioxidant, consists of the amino acid cysteine joined with an acetyl group making it more soluble and more biovailable than L-Cysteine alone. NAC , basically a precursor to glutathione, donates cystiene to form glutathione which is found in the body and produced in the liver. NAC has been shown in studies to prevent cell death.
Alpha Lipoic Acid (ALA)
Alpha Lipoic Acid is quite possibly the most novel, multifaceted, and important antioxidants available today. It neutralizes free radicals in both the aqueous and lipid portions of cells, is a key player in the synergism of other antioxidants extending the metabolic life of glutathione and Coenzyme Q-10, repairs liver damage, has blood lipid modulating properties lowering risk factors associated with cardiovascular disease (CVD), and enhances insulin function speeding the removal of glucose from the bloodstream and ushering it into muscles.
Beta-Sitosterol
Beta-Sitosterol is one of many phytosterols, phytochemicals naturally occurring in plants, whose structure closely resembles cholesterol. It has been shown to significantly lower cholesterol and has been used to treat hypercholesterolemia. Its major mechanisms of action are thought to be by preventing the absorption of dietary fat in the intestines where fat is digested and by increasing the flow of cholesterol binding bile acids in the digestive track excreting it in the feces. Beta-Sitosterol has also been proven effective in many studies in treating BPH (benign prostatic hypertrophy).
Saw Palmetto
Rich in phytosterols and fatty acids, Saw Palmetto has been used in treating BPH as well as male pattern baldness. This is largely due to its supposed ability to inhibit 5-alpha reductase, an enzyme responsible for converting precious testosterone into DHT, and interfering with DHTs binding ability to androgen receptors.
Quercitin
A highly active flavonoid, Quercitin, is yet another fierce antioxidant scavenging free radicals within the body. It most notably improves cardiovascular function by preventing the oxidation of LDL thus lowering cholesterol, lowering blood pressure, and also possesses anti-inflammatory properties.
Please note that I'm not a doctor or a writer this is only my opinion and the opinion of the sites I cut and pasted info from🙂
