with the coming offseason i thought id put together a few docs people could use to cut through the bro science and just get the facts about some proteins we hear about but few have actually used.
IGF-1 is the magic behind HGH, and when used responsibly can accomplish some dyamatic changes
some basics, IGF is produced naturally in the liver, this is a by product of the HGH signaling we all produce. it flows throughout the body and finding cell sites that have active receptors it binds to them, it actually binds to two receptors the IGF and the Insulin receptor but tits not really necessary to understand this second part
IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis
two types of IGF
IGF-1 LR3 - IGF-1 LR3 has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.
LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren't necessary, as IGF-1 LR3 will cycle the body binding to all muscle cells for about a day.
IGF-1 DES - DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5) times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutes, which means this is a very delicate chain. Therefore, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. In simple terms, it's best used for site injections, rather than overall growth.
In addition, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3.
so the part you care about, how do I use it and where to get it
for people using HGH
IGF-lr3 is best kept for workout days, i recommend only using the IGF-lr3 as a post work out in the amounts of 50 to 100 mcgs.
Why only after working out ? well you want the cells to send up the receptors, like a flag saying I have damage come fix me, if you use it before working out the igf will circulate looking for a home and it will mostly find active receptors in the intestines not the muscles.
sure if you want to get lean fast it can help, just understand the risk to rewards ratio when using Lr3 pre workout or on non workout days
to cycle IGf when not on HGH
id use between 50 and 80 mcgs a day taken in the morning right before a higher carb meal, IGF is very much like insulin and can make you go hypo should you already have low blood sugar so be safe eat after the shot. do this for up to 40 days, they dsay thats the limmit before desensitization cicks in.
IGF-des - the half life of Des makes it necessary to bring this stuff right to the gym with you, i recommend you begin the workout and get a set or two in before disappearing into a changing room to use this stuff. why because again you want the receptors active plus you want to have the presence of lactic acid in the muscle, this also is attractive to the Des and it rapidly binds to repair this
you need to do site injections with Des, so if you want to grow the biceps you have and to inject right into the muscle target, bilaterally meaning each side independently - i use 40 mcgs per side for a total of 80, you may go lower higher staying in the 50 -150 range
so where to get the real stuff ?
well finding real stuff is tough, most peptide places will not have real media grade IGF, and probable will just be filler in a vial
sponsors on EG who have reliable and real IGF is Sciroxx , both the lr3 and des are made in the same place as the HGH and i've seen quality and purity reports and i'm sure many of you are on other boards so you know the data and feedback from other places
I personally have used the LR3 twice and the Des once, definitely recommend using this as it's hit and miss going someplace else, toms probable is real but the cost is more typically as he does not do BOGO sales
there is increlex available from a vendor but that's several thousands and you have to add the Acetic acid to it yourself to extend the shelf life
i will begin logging the product soon, doing 8-10 weeks of rest time but we might be using some IGF without AAS, will wait and hear what the coach wants to do . you can always read back in my national prep to see my previous usage
questions are welcome, and I will try to answer in layman terns as practical usage and understanding are the goal here
I will post up some testing results from another site
IGF-1 is the magic behind HGH, and when used responsibly can accomplish some dyamatic changes
some basics, IGF is produced naturally in the liver, this is a by product of the HGH signaling we all produce. it flows throughout the body and finding cell sites that have active receptors it binds to them, it actually binds to two receptors the IGF and the Insulin receptor but tits not really necessary to understand this second part
IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis
two types of IGF
IGF-1 LR3 - IGF-1 LR3 has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.
LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren't necessary, as IGF-1 LR3 will cycle the body binding to all muscle cells for about a day.
IGF-1 DES - DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5) times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutes, which means this is a very delicate chain. Therefore, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. In simple terms, it's best used for site injections, rather than overall growth.
In addition, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3.
so the part you care about, how do I use it and where to get it
for people using HGH
IGF-lr3 is best kept for workout days, i recommend only using the IGF-lr3 as a post work out in the amounts of 50 to 100 mcgs.
Why only after working out ? well you want the cells to send up the receptors, like a flag saying I have damage come fix me, if you use it before working out the igf will circulate looking for a home and it will mostly find active receptors in the intestines not the muscles.
sure if you want to get lean fast it can help, just understand the risk to rewards ratio when using Lr3 pre workout or on non workout days
to cycle IGf when not on HGH
id use between 50 and 80 mcgs a day taken in the morning right before a higher carb meal, IGF is very much like insulin and can make you go hypo should you already have low blood sugar so be safe eat after the shot. do this for up to 40 days, they dsay thats the limmit before desensitization cicks in.
IGF-des - the half life of Des makes it necessary to bring this stuff right to the gym with you, i recommend you begin the workout and get a set or two in before disappearing into a changing room to use this stuff. why because again you want the receptors active plus you want to have the presence of lactic acid in the muscle, this also is attractive to the Des and it rapidly binds to repair this
you need to do site injections with Des, so if you want to grow the biceps you have and to inject right into the muscle target, bilaterally meaning each side independently - i use 40 mcgs per side for a total of 80, you may go lower higher staying in the 50 -150 range
so where to get the real stuff ?
well finding real stuff is tough, most peptide places will not have real media grade IGF, and probable will just be filler in a vial
sponsors on EG who have reliable and real IGF is Sciroxx , both the lr3 and des are made in the same place as the HGH and i've seen quality and purity reports and i'm sure many of you are on other boards so you know the data and feedback from other places
I personally have used the LR3 twice and the Des once, definitely recommend using this as it's hit and miss going someplace else, toms probable is real but the cost is more typically as he does not do BOGO sales
there is increlex available from a vendor but that's several thousands and you have to add the Acetic acid to it yourself to extend the shelf life
i will begin logging the product soon, doing 8-10 weeks of rest time but we might be using some IGF without AAS, will wait and hear what the coach wants to do . you can always read back in my national prep to see my previous usage
questions are welcome, and I will try to answer in layman terns as practical usage and understanding are the goal here
I will post up some testing results from another site
![IMG_3095[1].webp](/data/attachments/2/2703-5015867de44d487497a4d2b77836c52e.jpg?hash=siGgZwu55z)
