Myostatin dysfunction may impair muscle function, says research
Written by Administrator
New research finds myostatin inhibition may be detrimental to muscle.
Because the 'double muscling' of certain breeds of cattle, such as the Belgian blue, are thought to originate from a myostatin dysfunction, some believe that deliberately inhibiting myostatin with drugs will help produce hypertrophy (and increase strength) — after all, blocking myostatin is one treatment for muscle wasting diseases like muscular dystrophy.
However, new research published in the Scandinavian Journal of Medicine & Science in Sports disputes this idea, finding that myostatin inhibition actually results in less functional muscle. Researchers compared mice that had a myostatin dysfunction mutation with mice without the mutation and stimulated their calf muscles. The calf muscles of the non-mutated mice actually increased in mass more than those with the myostatin dysfunction. The authors concluded that myostatin dysfunction "impairs adaptation" of muscles to high functional demands.
Written by Administrator
New research finds myostatin inhibition may be detrimental to muscle.
Because the 'double muscling' of certain breeds of cattle, such as the Belgian blue, are thought to originate from a myostatin dysfunction, some believe that deliberately inhibiting myostatin with drugs will help produce hypertrophy (and increase strength) — after all, blocking myostatin is one treatment for muscle wasting diseases like muscular dystrophy.
However, new research published in the Scandinavian Journal of Medicine & Science in Sports disputes this idea, finding that myostatin inhibition actually results in less functional muscle. Researchers compared mice that had a myostatin dysfunction mutation with mice without the mutation and stimulated their calf muscles. The calf muscles of the non-mutated mice actually increased in mass more than those with the myostatin dysfunction. The authors concluded that myostatin dysfunction "impairs adaptation" of muscles to high functional demands.
