T4 and Hgh Efficacy studies

[TSizemore]

Here's a couple of research studies on T4 used in conjunction with Hgh......They are research studies, so don't freak on me...

Acta Endocrinol (Copenh). 1981 Apr;96(4):475-9.

The effect of growth hormone on the plasma levels of T4, free-T4, T3, reverse T3 an TBG in hypopituitary patients.

Gács G, Bános C.


Abstract


The plasma concentrations of thyroxine (T4), free thyroxine (free-T4), triiodothyronine (T3), reverse triiodothyronine (rT3), TSH and thyroxine-binding globulin (TBG) were measured in 19 children suffering from idiopathic growth hormone deficiency. Blood was taken before and one month after growth hormone treatment. Ten patients were hypothyroid (group 1) and 9 were euthyroid (group 2). The basal T3 and rT3 levels correlated well with the T4 concentrations. Free-T4 levels were very low in all the hypothyroid patients and proved to be the most reliable index of TSH deficiency. TBG concentration was high in th hypopituitary patients regardless of their thyroid function. Following growth hormone treatment T4, free-T4 and rT3 levels fell in both groups. The T3 concentration rose in group 1 but no change was seen in group 2. There was a significant correlation between the changes of T4 and T3, such that the increase in T3 level was greatest in those with only a slight reduction of T4 concentration and no T3 increase was seen with more marked T4 decreases. The plasma TBG concentration is enhanced in growth hormone deficiency causing relatively high T4 values. Growth hormone treatment reduces T4 secretion and affects the peripheral metabolism of thyroid hormones resulting in an increase of T3 and a reduction of rT3 concentration.


PMID: 6782790 [PubMed - indexed for MEDLINE]

 

[TSizemore]

Effect of thyroid hormone and growth hormone on recovery from hypothyroidism of epiphyseal growth plate cartilage and its adjacent bone.

Lewinson D, Harel Z, Shenzer P, Silbermann M, Hochberg Z.


Source

Laboratory of Musculoskeletal Research, Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa.


Abstract


Hypothyroidism was induced in young female Sprague-Dawley rats by the addition of methimazole (0.67 mg/ml) to drinking water for a period of 7 weeks (7-14 weeks of age). The responses of the articular cartilage, epiphyseal growth plate cartilage, epiphyseal trabecular bone, and metaphyseal trabecular bone in the proximal tibia were assessed by structural parameters. In addition, replacement therapies were introduced for the last 2 weeks of the experimental period. These included 0.7 U/kg BW human GH (hGH), 15 micrograms/kg BW L-T4 (T4), and a combination of hGH and T4 at the same doses. In the hypothyroid rats, the width of epiphyseal growth plate cartilage decreased by 27%, that of articular cartilage by 35%, epiphyseal trabecular bone volume by 30%, and metaphyseal trabecular bone volume by 66% relative to those in age-matched control tissues. T4 treatment led to a full restoration of the epiphyseal trabecular bone and surpassed by 40% the control value. The magnitude of the articular cartilage and the epiphyseal trabecular bone volume returned to control values, while that of metaphyseal trabecular bone was 68% of control values. Treatment with hGH did not improve the epiphyseal growth plate cartilage or articular cartilage. It did restore epiphyseal trabecular bone to almost normal values, but metaphyseal trabecular bone improved to only a small though significant level (45% of control value). The combination of T4 and hGH resulted in an additional enlargement in the width of the epiphyseal growth plate cartilage and an increase in metaphyseal trabecular bone volume compared to those in the T4 group. Qualitative examinations indicated that it was only in the T4 and T4 plus hGH groups that the lowest chondrocytes in the epiphyseal growth plate cartilage resumed their normal hypertrophied size. These results suggest that the change in the hypothyroid state do not rely solely on the lack of pituitary GH synthesis and secretion, as replacement by exogenous GH did not restore normal epiphyseal growth plate cartilage morphology or its remodeling into metaphyseal trabecular bone. Treatment with T4 (which restored endogenous pituitary GH to 30% of control levels) results in full recovery of the epiphyseal growth plate cartilage morphology along with its associated metaphyseal trabecular bone. In addition, it can also be concluded that the decrease in epiphyseal trabecular bone volume observed in the hypothyroid animals was due solely to the GH-deficient state that accompanied hypothyroidism.


PMID: 2912707 [PubMed - indexed for MEDLINE]

 

[Kuntrykok]

Thanks for the read T Size

 

[RockShawn]

If I'm reading these right, its further proof you should be supplementing t4 when on hGH. 200mcg is a good starting daily dose and get bloodwork done.

 

[TSizemore]

If I'm reading these right, its further proof you should be supplementing t4 when on hGH. 200mcg is a good starting daily dose and get bloodwork done.

I got more....but they were based on Fowl or lamb instead of rats

 

[Kuntrykok]

100 mcg is what I've been taking but only doing 2ius of hyges per day.

 

[TSizemore]

100 mcg is what I've been taking but only doing 2ius of hyges per day.

are you doing the 5 and 2 rotation on the GH?

 

[Kuntrykok]

4 on / 1 off

I have the 8 iu green tops and its easier for mixing.

 

[homegrown]

If I'm reading these right, its further proof you should be supplementing t4 when on hGH. 200mcg is a good starting daily dose and get bloodwork done.

Told you......

 

[RockShawn]

Told you......

I didn't doubt you a minute. In fact I posted a very similar thread about T4 and hGH. Right after you told me to get on T4. LoL. I got ergo's t4 initially, but ended up getting some from maxim and feel a lot better. I'm still fighting lethargy, could just be my busy ass life.

 

[TSizemore]

I didn't doubt you a minute. In fact I posted a very similar thread about T4 and hGH. Right after you told me to get on T4. LoL. I got ergo's t4 initially, but ended up getting some from maxim and feel a lot better. I'm still fighting lethargy, could just be my busy ass life.

I got to get some T4....to go along with the Nordi I got.....*sigh*

 

[Kuntrykok]

Mine is from Maxim too. Good stuff.

 

[bhcolex50x]

hey guys any updates? how did the 100 and 200mcg dosages treat y'all?

 

[Thaistick]

hey guys any updates? how did the 100 and 200mcg dosages treat y'all?

Bump for updates.

 

[TSizemore]

100mcg is an excellent starting dose, and even to stay there. Rock ended up going all the way to 400mcg, if I recall, but he had some other issues that required it. Experience and studies showed efficacy at 100mcg was excellent and getting to much higher led to thyroid issues.

 

[jshredz]

I'm currently at 200mcg running 4iu of hgh.
Even when i bump my hgh to 5iu I plan in staying at 200mcg.
Using research grade but if I was using pharm I would probably at around 100mcg of T4

 

[Wacker]

I always used 200mcgs a day when using HGH and even after 12 months my thyroid returned to normal full function two weeks after stopping, and I confirmed that with bloods at two weeks, 8 weeks, and then 4 months later. I was getting bloods for something unrelated but they were testing thyroid functions.

 

[Thaistick]

I always used 200mcgs a day when using HGH and even after 12 months my thyroid returned to normal full function two weeks after stopping, and I confirmed that with bloods at two weeks, 8 weeks, and then 4 months later. I was getting bloods for something unrelated but they were testing thyroid functions.

Very good to hear. I've heard the same from others about the thyroid recovering quickly from suppression. Always good to hear from another source. Thanks