Slayer's Den

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No Pain, All Gain​

Most drugs and supplements for joint pain have their drawbacks. Try this new trio for faster relief and long-term joint integrity.​

On paper, lifting weights is great for joint health. It strengthens the muscles around the joints, providing better support. Resistance training also increases the thickness and tensile strength of tendons and ligaments, enhancing their ability to handle mechanical stress. Joint stability and synovial fluid production are also improved by lifting weights.

So why do our joints hurt all the time? Why do we wake up stiff and make weird noises when we stand up?

Well, because we lift weights a lot, we push ourselves hard, and we often don't recover properly. Repetitive stress and inadequate recovery lead to overuse injuries. Heavy lifting and one-rep max attempts cause cartilage wear and tear. Our form isn't always textbook, and we accumulate micro-injuries to joints, tendons, and ligaments.

Not surprisingly, we take NSAIDs like ibuprofen for pain relief and maybe glucosamine/chondroitin to try to undo the damage. But based on newer research, there's a much better way to handle pain and keep our joints happy.

The Old Way​

Overusing NSAIDs isn't kind to our kidneys, livers, and stomach linings. According to some studies, they may even slow the healing of muscle strains and tendon injuries. Emerging research suggests that NSAIDs could even lower testosterone by disrupting the HPG axis and interfering with Leydig (testicular) cell function. So, use NSAIDs sparingly.

What about glucosamine and chondroitin supplements? A review of the research tells us that they work... a little. The effects are mild at best.

For example, glucosamine sulfate is moderately effective in reducing symptoms of knee osteoarthritis after using it for six months or longer. There's very little immediate pain relief, but it may slow disease progression in things like knee osteoarthritis. Most meta-studies on glucosamine report inconsistent results.

A 2015 meta-analysis in Annals of the Rheumatic Diseases found that chondroitin slightly reduces pain and improves function in knee and hip osteoarthritis. Some studies suggest it might slow cartilage breakdown. However, its benefits are often modest and slow to appear (three to six months).

In short, glucosamine and chondroitin supplements aren't going to hurt you, but their effects are slow and minimal.


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The New Way​

Newer studies show that a trio of supplements provide faster and more impactful benefits for joint pain and overall joint health.

1. Curcumin​

Curcumin works primarily through its anti-inflammatory and antioxidant properties. It inhibits NF-kB and COX-2, pathways that produce inflammatory compounds, and reduces oxidative stress, which contributes to cartilage breakdown.

• A 2014 study in Phytotherapy Research compared curcumin to ibuprofen in patients with knee osteoarthritis. Curcumin was as effective as ibuprofen in reducing pain but with fewer side effects.
• A 2016 meta-analysis in the Journal of Medicinal Food found that curcumin significantly reduced pain and improved physical function in osteoarthritis patients. It also reduced C-reactive protein (CRP), a marker of inflammation.
• In head-to-head studies, curcumin demonstrated stronger and faster pain relief than glucosamine and chondroitin and created a favorable environment for joint repair.

Most of these studies used standard curcumin or curcumin with piperine, but that's old technology. The newest, most effective form is micellar curcumin. Micellar Curcumin) formula contains solid lipid curcumin particles that produce 95 times more free curcumin in the bloodstream than curcumin with piperine (Gota VS et al, 2010). This more bioavailable formula allows you to use less and get much better results.

2. Fish Oil​

Omega-3s inhibit the production of pro-inflammatory cytokines and reduce leukotriene and prostaglandin synthesis via the COX-2 and LOX pathways. In English, it decreases joint swelling and stiffness. It also slows cartilage degradation by inhibiting enzymes like MMPs that break down cartilage. For pain relief, EPA and DHA are converted into resolvins and protectins, which help resolve inflammation and reduce pain sensitivity.

• A meta-analysis published in Rheumatology (2017) found that fish oil significantly reduced joint pain and morning stiffness and improved overall joint function in rheumatoid arthritis sufferers.
• A 2015 American Journal of Clinical Nutrition trial compared high-dose fish oil to placebo in knee osteoarthritis patients. The fish oil users saw significant improvements in joint pain and stiffness scores.
• A 2018 meta-analysis in Pain examined omega-3 supplementation across several studies and found that omega-3s reduced joint pain intensity and improved function.
• Fish oil works synergistically with curcumin, targeting inflammation through different pathways.

3. Collagen​

Collagen is the main structural protein in cartilage, tendons, and ligaments. We get it by eating animal bits: skins, simmered bones, organ meats, fish scales, and ox/pig/lamb tails. In other words, we don't get a lot of collagen these days. So, supplements help. Collagen, mainly type II, has these benefits:

• Stimulates chondrocytes (cartilage cells) to produce more collagen and extracellular matrix.
• Provides amino acids like proline, glycine, and hydroxyproline, essential for rebuilding cartilage.
• Reduces joint inflammation by modulating immune responses.
• In studies, taking hydrolyzed collagen peptides improved joint pain and stiffness and significantly reduced joint pain in athletes while training.

Every type of collagen has its benefits, so a blended supplement works best.