Viagra and Testosterone: Could the Blue Pill Really Increase Testosterone Levels?
By Ali Kuoppala
It’s of course the magical erectile dysfunction drug, Viagra, with the active ingredient sildenafil. There’s little to no doubt that anything with sildenafil will help men suffering with erectile dysfunction, as the active ingredient is a strong PDE-5 inhibitor that causes the tissue of the penis to “relax” allowing constant blood flow to the penile tissue.
But the actual mechanism of Viagra may not be limited to enhancing blood flow:
Sildenafil as a Prescription Testosterone Booster
There’s huge amounts of clinical research behind the world famous blue pill, and some of it is quite fascinating.
For example, this study conducted back in 2010, found out that sildenafil (the active ingredient in Viagra) was able to increase testosterone levels via elevating the levels of cAMP in isolated rat leydig cells. cAMP is a messenger between cells and hormones and elevated levels of cAMP in the body have been linked to increase testosterone levels. This is similar to how forskolin increases testosterone too.
But this study from last year is even more promising in regards of testosterone:
A scientist by the name of Matthew Spitzer gathered himself a group of 140 men who had low testosterone (330 ng/dl on average) and erection problems.
He then prescribed these men an optimized dosage of sildenafil (Viagra)…
…The men who were on alpha-blockers got 25 mg’s.
…The men who used Viagra for the first time got 50 mg’s.
…The men who had used plenty of Viagra before got 100 mg’s.
After optimizing the dosages, Spitzer observed the hormonal profiles of his subjects for 3-7 weeks.
The results were quite promising in terms of testosterone:
Total testosterone rose by 40% (103 ng/dl), free testosterone rose by 50%, and DHT levels also increased significantly (as to be expected when testosterone rises).
Spitzer was not exactly sure why this massive increase took place, but he believes that its caused by some sort of direct response mechanism in the testicles as the serum luteinizing hormone (LH) actually decreased. The decrease in LH also means that the increase in testosterone is not caused by the fact that the subjects probably had more sex during the trial.
Still, Viagra seems to create some very positive effects on serum testosterone levels of men with low testosterone (subjects were at 330 ng/dl on average).
Conclusion
Most prescription drugs are known for their testosterone lowering effects, but looking at the results of the studies above, it’s quite obvious that the active ingredient of Viagra (sildenafil) is a potent prescription testosterone booster.
I would like to know if Pfizer labels this boost in testosterone as a “side-effect” on the actual package.
In any case the active ingredient in Viagra increased total testosterone by 40% and free testosterone by 50% in a controlled human study.
By Ali Kuoppala
It’s of course the magical erectile dysfunction drug, Viagra, with the active ingredient sildenafil. There’s little to no doubt that anything with sildenafil will help men suffering with erectile dysfunction, as the active ingredient is a strong PDE-5 inhibitor that causes the tissue of the penis to “relax” allowing constant blood flow to the penile tissue.
But the actual mechanism of Viagra may not be limited to enhancing blood flow:
Sildenafil as a Prescription Testosterone Booster
There’s huge amounts of clinical research behind the world famous blue pill, and some of it is quite fascinating.
For example, this study conducted back in 2010, found out that sildenafil (the active ingredient in Viagra) was able to increase testosterone levels via elevating the levels of cAMP in isolated rat leydig cells. cAMP is a messenger between cells and hormones and elevated levels of cAMP in the body have been linked to increase testosterone levels. This is similar to how forskolin increases testosterone too.
But this study from last year is even more promising in regards of testosterone:
A scientist by the name of Matthew Spitzer gathered himself a group of 140 men who had low testosterone (330 ng/dl on average) and erection problems.
He then prescribed these men an optimized dosage of sildenafil (Viagra)…
…The men who were on alpha-blockers got 25 mg’s.
…The men who used Viagra for the first time got 50 mg’s.
…The men who had used plenty of Viagra before got 100 mg’s.
After optimizing the dosages, Spitzer observed the hormonal profiles of his subjects for 3-7 weeks.
The results were quite promising in terms of testosterone:
Total testosterone rose by 40% (103 ng/dl), free testosterone rose by 50%, and DHT levels also increased significantly (as to be expected when testosterone rises).
Spitzer was not exactly sure why this massive increase took place, but he believes that its caused by some sort of direct response mechanism in the testicles as the serum luteinizing hormone (LH) actually decreased. The decrease in LH also means that the increase in testosterone is not caused by the fact that the subjects probably had more sex during the trial.
Still, Viagra seems to create some very positive effects on serum testosterone levels of men with low testosterone (subjects were at 330 ng/dl on average).
Conclusion
Most prescription drugs are known for their testosterone lowering effects, but looking at the results of the studies above, it’s quite obvious that the active ingredient of Viagra (sildenafil) is a potent prescription testosterone booster.
I would like to know if Pfizer labels this boost in testosterone as a “side-effect” on the actual package.
In any case the active ingredient in Viagra increased total testosterone by 40% and free testosterone by 50% in a controlled human study.
