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FOR HANZO-BECAUSE HE'S FUNNY & CUTE

F.I.S.T.

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Thought id post this up for Hanzo per the discussion we were having in another thread. 8) ;D

DIM and Testosterone: Does the Indole-3-Carbinol in Cruciferous Vegetables Lower Estrogen and Boost T?

Ali Kuoppala 02/08/2015




DIM (3,3′-diindonylmethane) is a naturally occurring byproduct of indole-3-carbinol (IC3), and IC3 itself is a byproduct of glucosinolate glucobrassicin, which is a compound found in all crusiferous vegetables, such as: broccoli, cauliflower, cabbage, brussel sprouts, kale, and the like.

There has been much discussion about DIM and its effects on the reproductive system. It’s claimed to work by reducing estrogen, while also promoting optimal free-testosterone levels via reduced SHBG (Sex Hormone Binding Globulin). Hence, why many bodybuilders and health conscious men do consume cruciferous vegetables in hopes of raising T and reducing estrogen.

If you’re active on the “natural hormone optimization” circles, you must have seen recommendations about DIM or IC3 multiple times already.

But the big question is – does DIM or straight on IC3 work as claimed – or are they both just two farts in the wind?

[size=14pt]
Indole-3-Carbinol, DIM, Estrogen and the Big T


indole-3-carbinol and testosterone levels.The reason why most people use IC3 or DIM supplements, is to reduce their estrogen levels. There’s also some evidence that this could happen.

In particular, IC3 seems to help the liver to metabolize estrogen more efficiently (via upregulating the CYP1A2 enzyme)…

While also simultaneously converting strong estrogen molecules into less potent kind (via downregulation of the CYPB1B enzyme and upregulation of CYP1A2 enzyme). This should result in reduced estrogen levels and a more favorable estradiol/estrone ratio.

In a human study conducted nearly 20 years ago, 6-7 mg/kg of IC3 per day was able to significantly increase the clearance of estrogens via urine in both, men and women.

The supplement industry seems to have accepted the fact that it’s DIM (again DIM is just one of the many metabolites of IC3) that is responsible of these effects, and thus, extracted DIM would work just as well as IC3 or consumption of crusiferous vegetables…

…However, one animal study challenges this claim: The researchers from The University of Kansas Medical Center, found out that IC3 and tamoxifen (prescription estrogen receptor antagonist) both blocked estrogen (via different mechanisms), whereas extracted DIM had – even at the highest dose – ” no significant effects on any of the endpoints studied”.

Another study found out that isolated DIM might actually have some anti-androgenic effects in prostate cells, whereas IC3 isn’t known of having such effects.

All-in-all, the evidence points to the direction that IC3 supplementation, or consumption of crusiferous vegetables, would be more beneficial for ones estrogen balance than supplementation with the metabolite, DIM.



Conclusion


I have used DIM supplements in the past and I think I have even recommended extracted DIM in this blog before. However, now that I have seen more studies about IC3, isolated DIM, and their effects, I must say that I’m more or less convinced that IC3 and cruciferous veggies are much better of a choice than DIM.

Given that DIM was noted of having anti-androgenic effects in one in-vitro study (only in tumor cells though), it’s possible that IC3 could have similar effects too, which is why you should be monitoring your hormones when taking it.

NOTE: The effective dose of IC3 when used for blocking estrogen in average sized male would land in between 400-800 mg’s of IC3, or about 2-3 pounds of raw broccoli.[/size]
 
Based off 1 'animal study'. I can list several studies, on HUMANS, which shows otherwise, and you should have seen several of them in your "research" on the subject. Nice, try again. Try to c&p again, and please attempt to keep your personal biases out of it, as it makes you want to seek out an adverse opinion, and looking stupid in the meantime.

While we're here, let's discuss your extensive use of c&p, as I think some of the newer guys believe your posts are in your own words, when we know otherwise. 3 decades of cycling and you have to constantly c&p. Makes 1 wonder. Good day.
 
This is an important subject, and I don't want the c&p king to muddy the waters with the 1 broscience link he found. This is just 1 page of pubmed, the website for the NIH, on the benefits of DIM in regards to androgens. DIM has many, many benefits, not just estrogen modulation. Just put diindolylmethane in the search box and you'll be astounded on the number of studies that come up on the many different beneficial uses of DIM. You don't have to eat a couple lbs of broccoli either.

http://www.ncbi.nlm.nih.gov/pubmed/?term=diindolylmethane+androgen
 
lith56bigguy said:
Oh be nice Hanzo. Sure seems like your estrogen levels can use more DIM. Lol


Its ok Lith.He's actually comical in his attempts to disprove everyone else if they disagree with him.I actually enjoy his rants.He's like a cat going after a string im pulling.LMFAO.For such a "self proclaimed" educated guy,he's easier than my 6 yr old. 8)

I would'nt have posted this and titled it the way I did if I felt otherwise.

Keep doing what you're doing hanzo.I love it kid.Really.Not being sarcastic at all.
 
tkasch30 said:
Ooh crap here we go. Lol. For the good of everyone...lock this thread now! Lol


What are you talking about? Nothing wrong with a little discussion with conflicting opinions and data on it.Thats what the boards are all about.
😉
 
lith56bigguy said:
I always take DIM on cruise


Cool.Have you ever taken IC3 directly? Since dim is only one metabolite of IC3 and has proven much more effective,you may want to give that a g😵nly if needed of course.

Not saying if you feel dim is worth taking and has proven to be effective for you,to stop.But as hanzo has stated about this,and we all should already know,,you wont know what works best unless you try.If you believe you need additional help in controlling estrogen than the traditional methods,and feel dim is of help,why not try the substance that dim is only one part of?
 
Hanzo said:
This is an important subject, and I don't want the c&p king to muddy the waters with the 1 broscience link he found. This is just 1 page of pubmed, the website for the NIH, on the benefits of DIM in regards to androgens. DIM has many, many benefits, not just estrogen modulation. Just put diindolylmethane in the search box and you'll be astounded on the number of studies that come up on the many different beneficial uses of DIM. You don't have to eat a couple lbs of broccoli either.

http://www.ncbi.nlm.nih.gov/pubmed/?term=diindolylmethane+androgen


That link is interesting but im confused at why you posted it since it just links you to a number of different studies,some of which are about IC3?LOL.Also,many are not even related to the topic at hand............estrogen control.Maybe you can find a more relevant link to help us ignorant people. 8)
 
F.I.S.T. said:

Its ok Lith.He's actually comical in his attempts to disprove everyone else if they disagree with him.I actually enjoy his rants.He's like a cat going after a string im pulling.LMFAO.For such a "self proclaimed" educated guy,he's easier than my 6 yr old. 8)

I would'nt have posted this and titled it the way I did if I felt otherwise.

Keep doing what you're doing hanzo.I love it kid.Really.Not being sarcastic at all.

That's so hilarious. You really need to work on your comprehension. You're like a commie, you accuse everyone of behavior that you actually engage in.

You post in all large font, as if you feel the need to shout or have insecurity of not being noticed. All your posts are c&p, why? Because you don't understand what you're posting and you can't put it in lay terms.
 
I have ordered some DIM , on the good advice of my boy Hanz, and I haven't used it yet but have read and heard good things . I will def post when I use it !!!
 
F.I.S.T. said:


Cool.Have you ever taken IC3 directly? Since dim is only one metabolite of IC3 and has proven much more effective,you may want to give that a g😵nly if needed of course.

Not saying if you feel dim is worth taking and has proven to be effective for you,to stop.But as hanzo has stated about this,and we all should already know,,you wont know what works best unless you try.If you believe you need additional help in controlling estrogen than the traditional methods,and feel dim is of help,why not try the substance that dim is only one part of?

You totally miss the point. You really are 1 thick bastard. DIM has many, many uses. The links on pubmed will reveal all .... if you can use a search engine (try real hard, or have your 6 year old do it for you).
 
Hanzo said:
You totally miss the point. You really are 1 thick bastard. DIM has many, many uses. The links on pubmed will reveal all .... if you can use a search engine (try real hard, or have your 6 year old do it for you).


LMFAO.You really are a joke.

Maybe you can help edumacate me.You show your intelligence everytime you speak.Whenever one has to resort to name calling it always shows ones level of intelligence.I jsut hope next you dont say you're dog is better than my dogs.That would be low.

You go girl.Like I said,chase that string.LMFAO
 
I'm a joke because I post links to pubmed. You post 1 piece of broscience junk. Here kitty.

Oh yeah .... LMFAO. Retard.
 
Here you go. Good luck on understanding anything.

http://www.ncbi.nlm.nih.gov/pubmed/?term=diindolylmethane+estrogen
 
Not to toss TOO much of a monkey in this wrench, but aren't most of these foods rich in DIM, also known to lower T4-T3 conversion. I honestly don't know if its fact, but I've read and heard so.

tits vs. fat ass = pick your poison lol.
 
I've read that about spinach, I think because of glutathione levels? I've never seen that about cruciferous vegetables tho.
 
Hanzo said:
Here you go. Good luck on understanding anything.

http://www.ncbi.nlm.nih.gov/pubmed/?term=diindolylmethane+estrogen

You know,I really dont understand it.Maybe I am truly missing it because I have yet to see in any study in the multiple studies from the link you posted on AAS induced estrogen control.Ive seen quite a few studies on breat cancer cells,etc but I guess im missing the ones on MEN WHO TAKE IT TO CONTROL STEROID ASSOCIATED ESTROGEN VS THE TYPICAL PROTOCOLS!! LMFAO. I really must be a thick bastard as you said.Geez,now I really feel bad.

I think i'll still stick to as ive stated......WHATS PROVEN TO HAVE WORKED FOR ME and the other guys using their FIRSTHAND EXPERIENCE or "BRO-SCIENCE" as you called it while we are actually cycling, and not what some nerd in a lab says.

But as I said,you keep doing what you do poindexter.LOL.Seriously,no sarcasm.Im really enjoying your temper tantrums and name calling.At least I actually get you to post and contribute to the board instead of just lurking around the shadows like a spider.

By the way..............YOU'RE UGLY!!!! Bwahahahahahahahahaha
 
Hanzo,id like to sincerely apologize.You're not that ugly.To some I guess.LOL


Seriously,I do hope you keep posting to all my articles,or c&p as you call it.I do like to hear from you whether you agree with the author,or me or not.I love hearing all info.

As for all natural supps,everyone knows im all about it.Of course for me,food is always the best way to get in the nutrients you need but natural supps do have their place.I just like rattling youre cage once you get started.Its so easy.LMFAO.I don't want ti to go that route but you initiate it so I have to have fun with it.When I taste blood in the water,I have to go after it.

Anyway,as ive stated,keep doing what you're doing.At the least,it gets you posting and entertaining.

For everyone else,please dont take offense.Theres nothing wrong with a little disagreement.Thats what the boards are for.Discussion.Doesnt mean we're not family.
 

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