Designer steroid profiles

[jbryand101b]

MENTABOLAN

MENADIONE (METHYL NOR ANDROSTENEDIONE)

18opsj.jpg

Nomenclature:

7a-methyl-estra-4-en-3,17-dione

Anabolic/Androgenic Ratio:

960 : 165 - 510 vs testosterone by oral administration [1]

Synonyms:

7a-methyl-19-norandrostenedione, Mentabolan, MENT dione, Trestione.

History:

This is a brand new prohormone from PHF/IBE, never seen before on the prohormone or pharmaceutical market. It was synthesized and tested for anabolic and androgenic activity in rats in 1963 [1].

Function:

This is a prohormone to the black-market bodybuilding steroid and experimental contraceptive Trestolone, aka MENT. It's been described on some internet forums as "MENT dione", however since MENT is short for 7a-Methyl 19-Nor-Testosterone, this compound could more accurately be described as 7a-Methyl-19-Nor-Androstenedione, and given an acronym of it's own like MENAD or MENORAD.

Structure:

This prohormone is a "19-nor", or nandrolone derivative, and differs from nandrolone in that this hormone has a 17-ketone, where nandrolone has a 17b-hydroxy function, and also has the addition of a 7a-methyl group. In the same way as "Boladrol" is a 7a-methylated dione version of methyl testosterone, this compound is a 7a-methylated dione version of nandrolone.

Please don't confuse this compound (or the target steroid) with the widely-feared mibolerone, a.k.a. "cheque drops", which is a 17a-methylated version of trestolone (or dimethylated nandrolone). While MENT has the 7a-methyl/19-nor combination that produces a far stronger steroid than either configuration does alone, it lacks the 17a-methyl group that tends to dramatically increase liver toxicity.

Effects:

Effects should be similar to the injectable trestolone acetate. It's a strongly anabolic, moderately androgenic compound which should elicit significant strength gains and increased accumulation of muscle mass at an appropriate dosage. Users may also experience mood changes, such as an increase in confidence and subjective well being, and/or an increase in workout aggression.

Side Effects:

Side-effects may include those common to anabolic androgenic steroids, including but not limited to: blood pressure increases, HPTA disruption, adverse shifts in lipoprotein subfractions (increased LDL, lowered HDL cholesterol), acne, hair growth or loss. This product should not be used by women or teens. There's evidence that MENT aromatizes to some degree [2], so the gyno-prone may wish to either avoid this compound or co-administer an aromatase inhibitor (AI) or selective estrogen receptor modulator (SERM).

One side-effect that many might fear from this compound is the loss of libido and/or erectile dysfunction often seen with 19-nor derivatives (known colloquially as "deca-dick"). On the contrary, tests conducted with the target hormone trestolone (MENT) have found that it had a positive mood, libido, and erection-stimulating effect similar to that of testosterone [3], though this may not necessarily hold true with the supraphysiological doses used by bodybuilders.

Metabolism and Bioavailability:

As mentioned, this is a "dione" prohormone. In the body the ketone at C17 will be hydrolysed by 17b-hydroxysteroid dehydrogenase type 1 (17b-HSD1) into the active compound trestolone (MENT). Trestolone itself has been shown to be roughly 6 times as anabolic as methyl test by oral administration, and around 2.5 times as androgenic [4].

Unlike steroids like testosterone and DHT, trestolone shows no affinity for SHBG [5], so all of the converted compound in circulation should be bioavailable. For the same reason, it's likely to have a short terminal half-life so frequent dosing is suggested.

As most will know, testosterone and similar delta-4 steroids are typically converted to stronger compounds like DHT and DHT derivatives by the enzyme 5-alpha reductase (5AR). 19-nor compounds are an exception to this rule, with 5a-reduced nandrolone (or 19-nor DHT) being a far less potent androgen than nandrolone itself [6]. The 7a-methylation of trestolone (and by extension Mentabolan) hinders the reduction of this double bond, so delta 5(10) isomers are a major excreted metabolite [7]. This means that the 7a-methyl group not only makes the compound stronger by increasing androgen receptor affinity [8], but also reduces the ability of the body's enzymes to break it down into weaker metabolites.

MENT is a strong compound for several reasons (including as previously discussed steric hindrance to 5a-reduction, and an inability to bind with SHBG), but the primary reason for its strength is the increased androgen receptor affinity caused by the conformational changes of the 7a-methyl group [8][9]. The same will be true of the prohormone to MENT; Mentabolan.

References:
[1] Steroids 1, 299 (1963)
[2] J Steroid Biochem Mol Biol. 1994 Feb;48(2-3):297-304.
[3] J Clin Endocrinol Metab. 1999 Oct;84(10):3556-62.
[4] Acta Endocrinologica, Vol 43, Issue 3, 399-411
[5] J Androl. 1997 Jul-Aug;18(4):352-8.
[6] The Journal of Steroid Biochemistry and Molecular Biology Volume 53, Issues 1-6, 1995, 253-257
[7] Recent advances in doping analysis (12). Sport und Buch Strauß, Köln (2004) 261-268
[8] Steroids. 2009 Feb;74(2):172-97.
[9] The Journal of Steroid Biochemistry and Molecular Biology Volume 71, Issues 5-6, 1999, 213-222

henryv
😉

 

[jbryand101b]

MITHRAS AKA di methylated pheraplex.

Dimethandrostenol

Posted on May 6, 2013 by admin


Structural Image:
dimethandrostenol
Nomenclature:
2,17α-dimethyl-17β-hydroxy-5α-androst-2-ene or
2,17a-dimethyl-17b-hydroxy-5a-androst-2-ene

Name:
There’s no generally-accepted trivial name for this compound. It’s structurally very closely related to desoxymethyltestosterone (“pheraplex”), which was named methylandrostenol when first discovered as a doping agent. Methylandrostenol was subsequently shortened for convenience to the acronym ‘madol’. [1] By that rationale, since this compound has an additional methyl group, the trivial name dimethandrostenol would seem to fit. Desoxymethasterone would be an alternative way of describing it.

History:
Experiments at Syntex in the early 1960s established that steroids that lacked a C-3 oxygen atom, but had a double bond somewhere in the A-ring (particularly C2-C3), could still be effective anabolic agents; the oral activity of desoxymethyltestosterone in particular was noted. [2]
Additional research by the same team demonstrated that substitution with a methyl group to C2 unsaturated compounds increased oral activity further.



J. Med. Chem. 1963 Mar 1;6(2):162–6. [3]
Both this compound (the 2-methyl), and the 2-methylene analogue were found to have a strong anabolic effect and a good dissociation of anabolic and androgenic effects in preliminary testing. [3][4]


J. Med. Chem. 1962 Mar 1,5(2),406–8
J. Med. Chem. 1962 Mar 1;5(2):406–8. [4]
Like many other drugs such as methasterone and desoxymethyltestosterone, dimethandrostenol was never commercialized by Syntex. In 2013 it was released on to the dietary supplement market as Mithras from Iron Legion.

Anabolic Androgenic Ratio:
Preliminary testing indicated that it was very strong, with an anabolic to androgenic ratio of around 1000:200. The 2-methylene analogue was markedly weaker – though still potent. [3]


2-methylandrostenes table oral activity
J. Med. Chem. 1963 Mar 1;6(2):162–6. [3]
When subjected to further testing by researchers from the same lab, levator ani/ventral prostate/seminal vesicle figures of 1040:320:97 were confirmed. [5]


“The 2,17a-dimethyl derivative, a 3-deoxy steroid, had the remarkable activity of 1,040% on the levator ani, 97% on the ventral prostate, and 320% on the seminal vesicle.” [5]


delta 2 steroids by gavage
Endocrinology. 1963 Feb 1;72(2):259–66 [5]
These results were summarized in Julius Vida’s 1969 work Androgens and Anabolic Agents.


217a-dimethyl-17b-hydroxy-5a-androst-2-ene-Vida
Androgens and Anabolic Agents. 1969. Academic Press. p. 215 [6]

Relationship to other compounds:
Just as methylstenbolone can be described as a ‘hybrid’ of methyl-1-testosterone (M1T) and methasteron (superdrol), so this compound can be considered a ‘hybrid’ of methasteron (superdrol) and desoxymethyltestosterone (pheraplex).

steroid family
The “family” of structurally-related compounds illustrated above are all powerful anabolic agents (as can be seen by the anabolic:androgenic ratios quoted below) – and dimethandrostenol may be the strongest of all.

Table 1: Anabolic/Androgenic Ratios of a series of A-ring modified steroids

Compound Anabolic Androgenic Lab
LA VP SV
Desoxymethyltestosterone 437 119 218 Syntex [7]
Dimethandrostenol 1040 97 320 Syntex [5]
Methasterone 800 20 20 Syntex [8][9]
Methylstenbolone 660 90 170 Searle & Co. [10]
Methyl-1-testosterone 910 220 180 Searle & Co. [10]

LA = Levator ani (demonstrates anabolic potency). VP = Ventral prostate, and SV = Seminal vesicles (markers of androgenic potency)

Structure and Function:
Dimethandrostenol can be considered to be like methasterone (superdrol) with an additional double bond, or like desoxymethyltestosterone (phera-plex) with an additional 2-methyl group.
The presence of the adjacent double-bond causes the C-2 methyl group of dimethandrostenol to be planar (as with stenbolone and methyl stenbolone), unlike 2-methyl groups on saturated A-rings (like masteron and superdrol), which have to be in the alpha or beta position (alpha, in those examples).

Metabolism:
Dimethandrostenol cannot aromatize to form estrogenic metabolites, as it has no C4-5 double bond (it is ’5α-reduced’). For the same reason, it is not a substrate for (cannot be transformed by) the enzyme 5α-reductase (the enzyme that catalyzes the reaction that turns testosterone to DHT).
Potential metabolic transformations could include the reduction of the delta-2 double bond, formation of a 2-methylene metabolite, and various hydroxylation reactions. In desoxymethyltestosterone the double bond is fairly readily reduced; in dimethandrostenol it’s likely that the adjacent methyl group increases resistance to reduction of the double bond.
The toxicity of oral steroids appears to be closely related to both potency and resistance to metabolism. Given that this compound is extremely potent, and is likely to be fairly resistant to metabolism, it’s fair to assume it has a toxicity profile similar to other drugs of its class (i.e. those already mentioned).

References:
[1] Sekera MH, Ahrens BD, Chang Y-C, Starcevic B, Georgakopoulos C, Catlin DH. Another designer steroid: discovery, synthesis, and detection of “madol” in urine. Rapid Communications in Mass Spectrometry. 2005;19(6):781–4.
[2] Bowers A, Cross AD, Edwards JA, Carpio H, Calzada MC, Denot E. Steroids. CCV.1 Ring A Modified Hormone Analogs. Part I. Some Ring A Olefins. J. Med. Chem. 1963 Mar 1;6(2):156–61.
[3] Cross AD, Edwards JA, Orr JC, Berköz B, Cervantes L, Calzada MC, et al. Steroids. CCVI.1 Ring A Modified Hormone Analogs. Part II. 2-Methylene Androstanes and 2-Methyl-Δ1, Δ2 and Δ3-Androstenes2. J. Med. Chem. 1963 Mar 1;6(2):162–6.
[4] Cross AD, Edwards JA, Bowers A. Steroids. CLXXX.1 2-Methyl-Δ2-androstenes and 2-Methylene-androstanes. A New Class of Potent Anabolic Agents. J. Med. Chem. 1962 Mar 1;5(2):406–8.
[5] Dorfman RI, Kincl FA. Relative Potency of Various Steroids in an Anabolic-Androgenic Assay Using the Castrated Rat. Endocrinology. 1963 Feb 1;72(2):259–66.
[6] Vida, J. Androgens and Anabolic Agents. 1969. Academic Press. p. 215
[7] Kincl FA, Dorfman RI. Anabolic-androgenic potency of various steroids in a castrated rat assay. Steroids. 1964;3(1):109–22.
[8] Kincl, F. A. 1963. Unpublished data. In: Dorfman RI (ed) Methods in Hormone Research, Vol IV. Academic Press, New York, p32.
[9] Zaffaroni A. The effect of alkyl- and electronegative group substitution on steroidal hormone activity. Acta Endocrinol Suppl (Copenh). 1960;34(Suppl 50):139–45.
[10] Nutting EF, Klimstra PD, Counsell RE. Anabolic-Androgenic Activity of a-Ring Modified Androstane Derivatives. Acta Endocrinol. 1966 Dec 1;53(4):635–43.

© Total Flex Blog 2013
http://www.totalflexblog.com/prohormone-and-designer-steroid-profiles/dimethandrostenol/

total flex blog

 

[R2D2]

^^^that's mithras, right?

 

[jbryand101b]

^^^that's mithras, right?

bossman
yep. on phf everyone who's using it is saying it's amazing. but on am, no one who's used it has been happy.

 

[R2D2]

i just got some triumphalis. what's the word on that?

 

[jbryand101b]

not much buzz, so I cant honestly say. I'm sure over at phf though, all reviews are awesome.

 

[jbryand101b]

BOLASTERONE

for info if one is using boladiol (ph to bolasterone)

Here is the entire bolasterone write from Anabolics 9th edition.
Androgenic 300
Anabolic 575
Standard Methyltestosterone (oral)
Chemical Names 17beta-Hydroxy-7,17alpha-dimethylandrost-4-en-3-one 7,17-dimethyltestosterone
Estrogenic Activity high
-------------
Bolasterone is a modified form of testosterone. It differs by: 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, and 2) the introduction of a methyl group at carbon 7 (alpha), which inhibits 5-alpha reduction and shifts the anabolic to androgenic ratio in favor of the former. 7,17-dimethylated steroids also tend to be very resistant to metabolism and serum-binding proteins, greatly enhancing their relative biological activity.
-----------------

Bolasterone is an oral anabolic steroid structurally related to methyltestosterone. It differs only by the addition of a methyl group at c-7, which accounts for its given chemical name, 7,17-dimethyltestosterone. The added c-7 methyl group makes the activity of this steroid far removed from methyltestosterone, however, such that any direct comparison is difficult to justify. For starters, bolasterone is a fairly potent steroid, measured in human subjects to have approximately twice the anabolic effect of methandrostenolone.636 This is in contrast to methyltestosterone, which is considerably less potent than methandrostenolone. Despite being a testosterone derivative, bolasterone is also much more anabolic than androgenic in nature. At a given -therapeutic level, it is much less likely to cause androgenic/virilizing side effects. It does have one strong similarity to methyltestosterone, however, which lies in the fact that bolasterone too is quite estrogenic. Both agents are, therefore, most appropriately used during bulking phases or training.
--------------
Bolasterone was first described in 1959.637 It was closely evaluated for anabolic and androgenic effect approximately 3 years later.638 The drug was developed by Upjohn, and sold in the U.S. during the 1960's under the Myagen brand name. It was mainly indicated for the treatment of advanced breast cancer in women, although the agent was also investigated for its stimulatory effect on blood cells and its general anabolic (lean-tissue sparing) activity. Bolasterone was ultimately a short-lived drug, disappearing from the U.S. market shortly after its release. By the 1980's, bolasterone had been out of commerce for so long that it was all but forgotten among athletes. Although bolasterone is no longer produced, the drug remains listed in the U.S. Pharmacopeias, suggesting it would not be impossible to see this agent for sale (legally) in the U.S. again, perhaps under order by a private compounding pharmacy. The reemergence of an actual commercial bolasterone compound, however, remains very unlikely. Huh, little did he know...
---------------
Bolasterone is aromatized by the body, and is considered a highly estrogenic steroid due to its conversion to 7,17dimethylestradiol (an estrogen with high biological activity). Gynecomastia may be a concern during treatment, especially when higher than normal therapeutic doses are used. At the same time water retention can' become a problem, causing a notable loss of muscle definition as both subcutaneous water retention and fat! levels build. To avoid strong estrogenic side effects, it may' be necessary to use an anti-estrogen such as Nolvadex®. One may alternately use an aromatase inhibitor like
Arimidex® (anastrozole), which is a more effective remedyl for estrogen control. Aromatase inhibitors, however, can bel' quite expensive in comparison to standard estrogen maintenance therapies,and may also have negative effects on blood lipids.
--------------------
Although bolasterone is classified as an anabolic steroid, androgenic side effects are still possible with this substance.These may include bouts of oily skin, acne, and body/facial hair growth. Higher doses are more likely to cause such side effects. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Bolasterone is unaffected by the 5-alpha reductase enzyme, so its relative androgenicity is not affected by the concurrent use of finasteride or dutasteride. Note that studies administering 1mg and 2mg of bolasterone per day have shown no outward androgenic side effects in children and hypogonadotrophic males, as would be characterized by public hair growth, genital changes, voice changes, and acne. Higher doses remain likely to induce androgenic effects. Bolasterone is considered to have a comparable ratio of anabolic to androgenic effect as oxymetholone and methandrostenolone (superdrol).
-------------
Side Effects (Hepatotoxicity):
Bolasterone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage ofthe drug entry into the bloodstream following oral administration. ell-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Studies adm.inistering 1mg and 2mg of bolasterone daily for 6 weeks to 27 patients have demonstrated a trend toward increases in serum alkaline phosphatase (a marker of liver stress), although no significant untoward effects on the liver were documented.
The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.
------------------
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Bolasterone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Studies administering 1mg and 2mg of bolasterone daily for 6 weeks to 27 patients have demonstrated a trend toward increased serum cholesterol. Although no HDL and LDL breakdown was provided, it can be assumed based on the structure and route of administration that bolasterone significantly shifted the ratio of these two fractions of cholesterol further apart, measurably increasing atherogenic risk.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
-----------------
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
The above side effects are not inclusive. For more detailed discussion ofpotential side effects, see the Steroid Side Effects section ofthis book.
------------
Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability.639 This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization,this steroid should be taken on an empty stomach.
----------------
Administration (Men):
Clinical studies have demonstrated that significant nitrogen retention and weight gain can be induced with a daily dosage of 1-2mg per day. In the athletic arena, doses of 2-5 mg daily seem to be most reasonable, taken in cycles lasting no more than 6-8 weeks in length to minimize hepatotoxicity. This level is sufficient fer strong increases in muscle size and strength, although such gains will likely be accompanied by significant water retention.
----------------
Administration (Women):
Bolasterone was not widely used with women in clinical medicine. When applied, it was most often used as a secondary medication during inoperable breast cancer, when other therapies have failed to produce a desirable effect. The dosage used for this application would be as high as 10 mg per day, a level that has caused significant virilization among patients. Bolasterone is generally not recommended for women for physique-.or performanceenhancing purposes due to its very strong nature and tendency to produce virilizing side effects.
------------------
Bolasterone is no longer produced as a prescription drug, although a handful of underground laboratories have taken to selling this material.

jbryand101b;2613936
I had beta tested this compound (boladrol aka boladiol) from phf supplements before they released it, and ran it at 8-12mg e/d.
it was super potent. an my prostate swole up like crazy. trying to piss at 3am an nothing comes out sucks.
strength gains though were redonkulous.

It's sad that I was later informed the finished product (after the first round of batches) had been tested by a 3rd party, and was tainted, and no longer contained the compound claimed.

it's a shame, would of gave people access to a hard to find (pure) compound.

 

[jbryand101b]

in case one is wondering, diol compounds are incapable of aromatization.

they are also able to bind with an interact with the androgen receptor, needing no conversion, although, not as strongly as a 3-ketone counter part.

meaning something like boladiol would be an active steroid, needing no conversion, and still be dryer than the 3-ketone bolasterone, but not as potent mg for mg.

 

[R2D2]

what was the boladiol tainted with?

 

[goodfella]

in case one is wondering, diol compounds are incapable of aromatization.

they are also able to bind with an interact with the androgen receptor, needing no conversion, although, not as strongly as a 3-ketone counter part.

meaning something like boladiol would be an active steroid, needing no conversion, and still be dryer than the 3-ketone bolasterone, but not as potent mg for mg.

jbryand101b
AHHHHHH SHITTT 😛 ^^^I SEE THIS NIGGA ALL OVER THE NET TALKIN PH's! Damn, wish I would have seen your post on the iron legion goods. True about how most all reviews at phf seem to always be positive on stuff -_- Their mods/reps are fucking idiots or 18 y/o's. Kinda reminds me of eroids lol.

You have any word/feedback on halo from celtic labs?

 

[jbryand101b]

what was the boladiol tainted with?

bossman

I don't, but back before Patrick Arnold was getting payed $$$ to use his name, cough, I mean test phf's products, I was informed he has randomly tested boladrol, and that it didn't contain the compound.

when I brought this to light, I was pm'd by someone very close to pa and the epharm team, asking to delete the post, and not get pa in trouble, as he gets payed for his "ask pa" sub forum at phf.com.

so take that for what you want. now everyone wants to get tested by pa, and now everyone's ph's are good!

 

[jbryand101b]

AHHHHHH SHITTT 😛 ^^^I SEE THIS NIGGA ALL OVER THE NET TALKIN PH's! Damn, wish I would have seen your post on the iron legion goods. True about how most all reviews at phf seem to always be positive on stuff -_- Their mods/reps are fucking idiots or 18 y/o's. Kinda reminds me of eroids lol.

You have any word/feedback on halo from celtic labs?

goodfella
I don't, but it's phf's new company, and again, all the results at phf's forum are all stellar reviews.

not much buzz for their products on other forums. but not everyone is all over the place as I am.

I'm going to post a thread on the designer steroids, and where to get legit hard to find ones (m1t, m4ohn) and which brands I know for a fact are legit.

 

[jbryand101b]

METHYL 1-TESTOSTERONE (M1T)

Nomenclature:

17a-methyl-1-testosterone, or 17a-methyl-17b-hydroxy-1-androsten-3-one, or 17a-methyl-5a-androst-1-ene-3-one-17b-ol

Anabolic/Androgenic Ratio:

910-1600:100-220 vs. methyl test by oral administration. [1][2]

Synonyms:

Methyl-1-testosterone, 17aa-M1T, M1T, Methyl Dread, M-One-T, 17a-methyl-dihydroboldenone

History:

It was originally synthesized as early as 1962 at Searle Laboratories though, like most compounds researched in the 1960s, never made it as far as human testing. Although it was extremely anabolic, it also possessed fairly strong androgenic qualities and was consigned to the annals of history, until it was unearthed decades later to take the bodybuilding supplement industry by storm.

M1T was the culmination of an arms race in the industry during the late 90s and early 2000s that started when Patrick Arnold released the prohormone to testosterone 4-androstenedione. He then followed it up with the hugely popular 1-androstenediol, a 1-testosterone precursor. Other firms took this one step further by producing the already-active 1-testosterone, and finally Legal Gear (now LG Sciences) upped the ante by bringing to market Methyl 1-Testosterone (M1T), which unlike the previous compounds was an entirely synthetic (non-naturally occurring) fully active oral steroid. [3]

The popularity of this and other synthetic hormones (along with a couple of sports doping scandals) attracted a lot of unwanted attention to the industry, resulting in the Anabolic Steroid Control Act of 2004 which saw M1T, 1-AD, 4-AD, and every prohormone and steroid the US govt. could think of added to Schedule III of the Controlled Substances Act, making them illegal to sell or possess, [4] though no legislative action has been taken against it in the UK at the time of writing.

Structure and Function:

This is a 17a-methylated compound, making it highly orally available. It lacks the delta-4 double bond of testosterone, having a 1,2 double bond instead. This means that it will not aromatise, and it will not 5a-reduce in androgen-sensitive tissues like testosterone can (since it's 5a-reduced already). Metabolism is limited, to a large extent, to reduction of the double bond and hydroxylation of the 3-ketone. [5]

Fig 1. Metabolism of 1-androstenes [6] (image simplified for illustrative purposes).

Effects:

Users can expect significant and rapid weight gain accompanied by extreme gains in strength. This is not a compound to be underestimated and would be well-suited to those looking for immediate results. Some of the weight gained will be in the form of fluid retention that will be lost upon cessation, though long-lasting physique improvements can be made by taking full advantage of the short highly anabolic window of the cycle.

Side Effects:

Many have assumed that M1T aromatises, however that is structurally impossible. What is possible - and much more likely in my opinion - is that it is an inhibitor of 11b-hydroxylase, which would account for both the apparent water retention ("bloat") and high blood pressure some users experience.

Inhibition of 11b-hydroxylase can lead to increased renin secretion which results in higher levels of aldosterone, a mineralocorticoid that causes high blood pressure and water retention through sodium retention and the excretion of potassium. [7]
One study on bodybuilders found far higher levels of aldosterone in the steroid-taking group than in the non-steroid taking group - and these changes remained far past the end of their cycles. [8]
This may or may not be the case for M1T (and many other steroids), but it is food for thought, particularly as a previous study pointed the finger at aldosterone as a cause of left ventricular hypertrophy, and suggested that it's heart remodelling effects may be unrelated to it's blood-pressure increasing effects. [9]

Liver toxicity is also a concern with this compound. While there are many 17a-methylated compounds on the market, they are not all equally hepatotoxic at like-for-like dosages. Protodrol for example is likely to impart minimal hepatic impact at doses of 100mg for six weeks, while 20mg of M1T for a couple of weeks will significantly adversely affect liver function markers. Abuse of this drug with high doses for long periods of time can result in intrahepatic cholestasis (jaundice), and for this reason cycles should be kept short, low-dosed, and alcohol-free.

Recommended Dosages and Cycle Durations:

Most trainees should see dramatic results at 10mg/day for two to three weeks, the cautious may do well on 5mg, while the more reckless will use higher doses and durations. Although cycles are short, it's a strong suppressive compound, so a full SERM PCT protocol is advised.


References:

[1] Acta Endocrinol December 1, 1966 53 635-643 [link]
[2] J. Med. Chem., 1965, 8 (1), pp 48–52 [link]
[3] The History Of Pro-Hormones on Super Human Radio
[4] Senate Bill 2195
[5] Recent Advances in Doping Analysis (14), Sport und Buch Strauss, Cologne, Germany, 2006, pp. 249–258.
[6] J Steroid Biochem Mol Biol. 2009 May;115(1-2):44-61.
[7] Cardiovascular Toxicity of Anabolic Steroids, Annual Review of Pharmacology and Toxicology Vol. 33: 497-520
[8] Recent advances in doping analysis (12). Sport und Buch Strauß, Köln (2004) 395-401
[9] Clin Exp Pharmacol Physiol. 2001 Oct;28(10):783-91.

henryv;2389394
I know a lot of you guys are like, oh now, m1t is horrible. but it isn't. It's prob my favorite compound next to superdrol.

I respond well to it. super potent. great kickstart if you have test.

 

[jbryand101b]

METHYL 4-HYDROXY NANDROLONE (M4OHN)

Nomenclature:

4-hydroxy-17a-methyl-19-nortestosterone or 4-hydroxy-17a-methyl-17b-hydroxyestr-4-en-3-one or 17a-methyl-3-oxo-19-norandrostene-4,17-diol

Anabolic/Androgenic Ratio:

1304:281 vs. methyl testosterone by oral administration, and 1304:1024 vs. methylnortestosterone by oral administration. [1]

Synonyms:

M4OHN, methyl hydroxy nandrolone, MOHN, oxavar

History:

This compound is first described in the literature in 1964, when researchers from Milan, Italy, explored the effects of adding a hydroxyl group at C-4 to a variety of steroids. [2]
It was launched on the prohormone market in 2004 as a bulk powder by Designer Supplements and 1fast400. The first capped product was Oxavar by Gaspari Nutrition.
It was shortlived, however, since the Anabolic Steroid Control Act of 2004 [3] saw it added to Schedule III of the Controlled Substances Act, making M4OHN illegal to sell or possess in the USA. It resurfaced in the UK in late 2010; no legislative action has been taken against it in the UK at the time of writing.

Structure and Function:

This is a oral nandrolone-derived steroid. It differs from nandrolone in that it has a 17a-methyl group to improve oral bioavailability, and a 4-hydroxyl group that increases the dissociation of anabolic and androgenic effects. It is essentially a 19-nor version of the steroid oxymesterone.

G. Sala, in his paper on the biological properties of 4-hydroxy-3-keto-Δ4-steroids [2], observed that "4-hydroxy-17a-methyl-19-nortestosterone presents a strong increase of the myotrophic and of the androgenic effect, with a moderate increment of the therapeutic index, as compared with 17a-methyl-19-nortestosterone".

This increase in effect was only seen with oral administration, not with subcutaneous injection of the compound, so he goes on to say that he believes this is due to the hydroxylation at C4 increasing "intestinal absorption of 17a-methyltestosterone derivatives", in addition to "favoring dissociation between myotrophic and androgenic activity".

The 4-hydroxyl group also abolished the progestational effects of all of the testosterone and nortestosterone derivatives studied. The results of his observations of the compound are summarized below:

The addition of the 4-hydroxyl function is likely to hinder (though not prevent) the reduction of the C-4,5 double bond. This is particularly true of 17a-methylated steroids such as this one. [4]
Whereas testosterone derivatives typically 5a-reduce to stronger androgens, 19-nortestosterone derivatives typically 5a-reduce to weaker androgens. This goes some way to explaining why M4OHT (methyl hydroxy testosterone) is more anabolic and less androgenic than methyl test, while M4OHN (methyl hydroxy nandrolone) is more anabolic and much more androgenic than methyl nandrolone.

Effects:

While the anabolic:androgenic profile would suggest that this was a strong mass-builder, user feedback would suggest it is instead an effective cutter and best used by those looking to shed excess fat.

Side Effects:

One of the issues surrounding nandrolone derivatives, particularly 17a-methylated nandrolone derivatives, is their potential for progestational activity. Fortunately this compound is an exception to the rule, having no progestational effects. Any nipple sensitivity on-cycle will therefore be estrogen related and should be dealt with by a SERM or aromatase inhibitor.
The standard list of steroidal side-effects listed in the other profiles will also apply to this compound.

Recommended Dosages and Cycle Durations:

Due to it's strong profile this compound was originally released in 2mg caps, with other manufacturers dosing them similarly at 2-4mg. Users often ran it much higher, with 12mg being common though some reported the best effects at 40mg or even higher.
The clone currently available on the UK market is dosed at 10mg per cap, which will make it much easier and more cost-effective to experiment with higher dosing. Since it's a methylated compound cycles are generally 6 weeks or less to minimise the risk of hepatic injury.


References
[1] Vida J.: Androgens and Anabolic Agents. Academic Press, New York (1969) p. 280.
[2] Hormonal Steroids Vol 1, p.67. Academic Press, New York, 1964.
[3] Senate Bill 2195
[4] J Steroid Biochem Mol Biol. 2009 May;115(1-2):44-61.

henryv;2389396

 

[jbryand101b]

I may have to clean this up and sticky it..... 😉

TSizemore
trying to clean it up now, sorry 🙁

 

[jbryand101b]

ALPHA ONE (METHYL 1-ANDROSTENEDIOL)

THIS IS a compound great for those who are a bit afraid of the power of m1t. it brings similar gains, but being a diol, 95% of reports show this to be much nicer on the body than m1t. (the other 5% most likely get excellent conversion into m1t)

Nomenclature: Methyl-1-Etiocholenolol-Epietiocholanolone, or 17a-methyl-1-androstene-3b,17b-diol

Synonyms: Alpha-One, Methyl-1-Alpha, M1A, Methyl-1-Androstenediol

Originally marketed by Legal Gear as Methyl-1-Alpha, this is 17a-methylated version of 1-AD, so whereas 1-AD converted to 1-Test, M1AD converts to M1T (aka Methyl 1-Testosterone). While M1T is banned in the US, there is currently no legislation against this "prohormone" to it.

According to Vida, it's roughly as androgenic as methyl test, but around four times as anabolic (M1T is roughly twice as strong as M1A on both counts, according to the same source). The conversion rate to M1T should be fairly high, plus in its unchanged diol configuration I would expect some receptor affinity. Methyl 1-Test is highly hepatotoxic (more so than most methylated orals), and I don't see why this would be markedly less so, since they are both 17a-methylated (which prevents deactivation through metabolism of the 17b-OH), and the covalent bond structure is the same. This concerns me, as people typically run M1A at several times the dosage of M1T. I guess blood work will tell.
I would not recommend this compound to beginners. Strength and size gains should be rapid and profound, with some of that being due to increased water retention. Side effects may include (but are not limited to) high blood pressure, lethargy, back and shin pumps, loss of sex-drive, and adverse shifts in lipoprotein subfractions. While on paper neither this compound nor its metabolites aromatise, plenty of M1T users have reported on-cycle gyno so it would be prudent to assume a degree of risk with this compound as well.

Cycle lengths should be short and relatively low dosed IMO, two to four weeks at 20 - 40mg (some users will choose to go up to 60mg), followed by an appropriate SERM PCT protocol.

henryv;1678167

 

[goodfella]

I don't, but it's phf's new company, and again, all the results at phf's forum are all stellar reviews.

not much buzz for their products on other forums. but not everyone is all over the place as I am.

I'm going to post a thread on the designer steroids, and where to get legit hard to find ones (m1t, m4ohn) and which brands I know for a fact are legit.

jbryand101b
Sounds good

 

[jbryand101b]

there is a lot of buzz surrounding trestobol. (celtic labs)

trest is 7a methyl nor testosterone.

the 7a methyl prevents the compound from becoming a weaker 5a reduced version of the androgen.

(5a reduced nor test is much weaker than nor test)

it shouldn't have good oral bioavailability d/t there being no 17a protection. but users are reporting good gains from the product.

but I haven't used it myself, d/t not wanting to get burned on bunk/underdosed/contaminated products.

 

[R2D2]

i haven't been all that impressed with trestobol at 40 mg. i think it would get real expensive to have a good oral run with it. maybe my expectations were too high tho, or maybe my diet hasn't been good enough.

 

[jbryand101b]

i haven't been all that impressed with trestobol at 40 mg. i think it would get real expensive to have a good oral run with it. maybe my expectations were too high tho, or maybe my diet hasn't been good enough.

bossman
75mg to 100mg from what I understand is where people have been running trestobol.

where if you inject, 30-50mg is the perfect dosage, with 50mg having a lot of estrogenic sides.